细胞色素P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

细胞色素P450 相关产品（165）

货号	产品名	Cas
PL14606	(-)-Ketoconazole	142128-57-2
PL14530	(R)-Mephenytoin	71140-51-7
PL14557	(±)-N-3-Benzylnirvanol	93879-40-4
PL14334	1-Dodecylimidazole	4303-67-7
PL14550	1-Ethynylnaphthalene	15727-65-8
PL14538	1-Ethynylpyrene	34993-56-1
PL14597	2,3-Dimethoxybenzaldehyde	86-51-1
PL14573	2,4,6-Tribromophenyl caproate	16732-09-5
PL14541	4'-Methylchrysoeriol	4712-12-3
PL14542	4-(Trifluoromethyl)umbelliferone	575-03-1
PL14595	4-Chlorosalicylic acid	5106-98-9
PL14591	5-Dehydroepisterol	23582-83-4
PL12136	6-Chloro-7-deazapurine-β-D-riboside	16754-80-6
PL14580	Acetyllovastatin	81189-92-6
PL14565	ACP-5862	2230757-47-6
PL08047	ADL-5859	850173-95-4
PL14564	AMG-208	1002304-34-8
PL14584	Amphotericin B methyl ester	36148-89-7
PL14613	AN2718	174672-06-1
PL14402	Anastrozole-d12	120512-32-5