Epigenetic Reader Domain（表观遗传读者域）

Epigenetic regulators of gene expression and chromatin state include so-called writers, erasers, and readers of chromatin modifications.Well-characterized examples of reader domains include bromodomains typically binding acetyllysine and chromatin organization modifier (chromo), malignant brain tumor (MBT), plant homeodomain (PHD), and Tudor domains generally associating with methyllysine. Research on epigenetic readers has been tremendously influenced by the discovery of selective inhibitors targeting the bromodomain and extraterminal motif (BET) family of acetyl-lysine readers. The human genome encodes 46 proteins containing 61 bromodomains clustered into eight families. Distinct experimental approaches are used to identify the first BET inhibitors, GSK 525762A and (+)-JQ-1.

The Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. This function of EZH2 is important for cell proliferation and inhibition of cell differentiation, and is implicated in cancer progression. Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2. In many types of cancers including lymphomas and leukemia, EZH2 is postulated to exert its oncogenic effects via aberrant histone and DNA methylation, causing silencing of tumor suppressor genes.

p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase.

Epigenetic Reader Domain（表观遗传读者域）相关产品（182）

货号	产品名	Cas	产品描述
PL13398	(+)-JQ-1-aldehyde
PL13467	(+)-JQ1 PA	2115701-93-2
PL13410	(R)-BAY1238097	1564269-85-7
PL13412	(Rac)-BAY1238097	1564268-19-4
PC10028	(S)-(+)-2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂卓-6-基)乙酸叔丁酯.	1268524-70-4	(+)-JQ-1 (JQ1) 是一种有效特异性的可逆 BET bromodomain 抑制剂，抑制 BRD4(1/2) 的 IC50 分别为 77 nM 和 33 nM。(+)-JQ-1 激活自噬 (autophagy)。
PL13455	(S)-JQ-35	1349719-98-7
PL13416	653-47 hydrochloride	1224567-46-7
PL13490	666-15	1433286-70-4
PL13487	A-485	1889279-16-6
PL10621	A1874	2064292-12-0
PL12275	ABBV-744	2138861-99-9
PL10673	ACBI1	2375564-55-7
PL13451	Alobresib	1637771-14-2
PL13397	Amredobresib	1610044-98-8
PL13502	Apabetalone	1044870-39-4
PL10632	ARV-771	1949837-12-0
PL10628	ARV-825	1818885-28-7
PL10629	AU-15330	2380274-50-8
PC10208	AZD 5153	1869912-39-9
PL13482	AZD5153 6-Hydroxy-2-naphthoic acid	1869912-40-2

Epigenetic Reader Domain（表观遗传读者域）

Epigenetic Reader Domain（表观遗传读者域） 相关产品（182）

Epigenetic Reader Domain（表观遗传读者域）相关产品（182）