AKT

Akt/PKB (Protein kinase B), a serine/threonine protein kinase with antiapoptotic activity, is one of the major downstream targets of PtdIns(3,4,5)P3 signaling pathway. It contains a pleckstrin homology domain (PH domain) that specifically binds PtdIns(3,4,5)P3 on the plasma membrane. Akt phosphorylation and activation are directly determined by the level of PtdIns(3,4,5)P3 on the plasma membrane, which is regulated by PI3K.

Akt consists of three isoforms: PKBα/Akt1, PKBβ/Akt2 and PKBγ/Akt3. Akt isoforms have an N-terminal PH (pleckstrin homology) domain and a kinase domain, which are separated by a 39-amino-acid hinge region. Catalytically active Akt regulates the function of numerous substrates involved in cell survival, growth, proliferation, metabolism and protein synthesis.

Akt is a crucial mediator of cell survival and its deactivation is implicated in various stress-induced pathological cell death and degenerative diseases.

AKT 相关产品（82）

货号	产品名	Cas
PC54292	(-)-Deguelin	522-17-8
PL04311	(E)-Akt inhibitor-IV	959841-49-7
PC15504	10-DEBC hydrochloride	925681-41-0
PC15486	3CAI	28755-03-5
PC15426	A-443654	552325-16-3
PL03299	A-674563	552325-73-2
PL03301	A-674563 hydrochloride	2070009-66-2
PL02986	ACT001	1582289-91-5
PL04512	Afuresertib	1047644-62-1
PL04513	Afuresertib hydrochloride	1047645-82-8
PC15528	Akt Inhibitor IV	681281-88-9
PC15427	AKT inhibitor VIII	612847-09-3
PL01357	AKT Kinase Inhibitor	842148-40-7
PL01358	AKT Kinase Inhibitor hydrochloride
PL04793	AKT-IN-1	1357158-81-6
PL02810	AKT-IN-3	2374740-21-1
PL04992	AKT-IN-6	1430056-54-4
PC15462	AKT/mTOR Set I
PL05089	Akt1/Akt2-IN-1	893422-47-4
PL04360	ALM301	1313439-71-2