GSK-3

Glycogen synthase kinase 3 (GSK-3) is a multifunctional serine/threonine kinase consisting of two isoforms, alpha and beta. It is a highly conserved negative regulator of receptor tyrosine kinase, cytokine, and Wnt signaling pathways. Stimulation of these pathways inhibits GSK-3 to modulate diverse downstream effectors that include transcription factors, nutrient sensors, glycogen synthesis, mitochondrial function, circadian rhythm, and cell fate. GSK-3 also regulates alternative splicing in response to T-cell receptor activation, and recent phosphoproteomic studies have revealed that multiple splicing factors and regulators of RNA biosynthesis are phosphorylated in a GSK-3-dependent manner.

The malfunction or aberrant activity of GSK-3 leads to several of disorders, such as Alzheimer's disease (AD) and other neurodegenerative pathologies, and other type of diseases as diabetes, cardiovascular disorders and cancer. GSK-3 is also related to innate immune response against pathogens, which makes GSK-3 an excellent target for therapeutic intervention.

GSK-3 相关产品（63）

货号	产品名	Cas
PL02799	(E/Z)-GSK-3β inhibitor 1	3367-88-2
PL02682	(R)-BRD3731	2056262-08-7
PL02315	(Rac)-BRD0705	1597440-03-3
PC15483	1-Azakenpaullone	676596-65-9
PL01972	5-Iodo-indirubin-3'-monoxime	331467-03-9
PL02483	7BIO	916440-85-2
PL02160	9-ING-41	1034895-42-5
PC15895	A 1070722	1384424-80-9
PL01672	Alsterpaullone	237430-03-4
PL01509	AR-A014418	487021-52-3
PL03748	AZD1080	612487-72-6
PL04524	AZD2858	486424-20-8
PC15488	Bikinin	188011-69-0
PC15868	BIO-acetoxime	667463-85-6
PL01866	BIP-135	941575-71-9
PL03760	Bisindolylmaleimide I hydrochloride	176504-36-2
PL02314	BRD0705	2056261-41-5
PL02683	BRD3731	2056262-07-6
PL02316	BRD5648	2056261-42-6
PC15879	CHIR 99021 trihydrochloride