Smoothened

Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways.

The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.

Smoothened 相关产品（21）

货号	产品名	Cas
PC15904	ALLO-1	37468-32-9
PL11319	ALLO-2	1357350-60-7
PL11320	BMS-833923	1059734-66-5
PL11322	Glasdegib	1095173-27-5
PC15877	GSA 10	300833-95-8
PC15832	HhAntag	496794-70-8
PC15856	LDE225 (NVP-LDE225,Erismodegib)	956697-53-3
PC15834	LDE225 Diphosphate	1218778-77-8
PL11315	LEQ506	1204975-42-7
PC15876	M 25
PL11324	MK-4101	935273-79-3
PC15897	MRT 10	330829-30-6
PL11312	MRT-14	1263131-83-4
PL11317	MRT-81	1263132-08-6
PL11316	MRT-83	1263131-92-5
PL11313	MRT-83 hydrochloride	1359944-60-7
PL11321	SAG dihydrochloride
PL11323	SAG hydrochloride	2095432-58-7
PL11314	SAG-d3
PL11318	Saridegib	1037210-93-7