Proteasome

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into amino acids and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Proteasome 相关产品（48）

货号	产品名	Cas
PL10714	(1S,2R)-Alicapistat	2221010-57-5
PL10731	(1S,2S)-Bortezomib	1132709-14-8
PL09117	20S Proteasome-IN-1	858557-69-4
PL10713	5-Amino-8-hydroxyquinoline	13207-66-4
PL10715	Ac-Nle-Pro-Nle-Asp-AMC	355140-49-7
PC16202	Aclacinomycin A	57576-44-0
PL09242	Alicapistat	1254698-46-8
PL10718	Alloxan hydrate	2244-11-3
PC16212	AM 114	856849-35-9
PL07778	Bortezomib-d8
PL09395	Calpain-2-IN-1	144231-85-6
PL10729	Capzimin	2084868-04-0
PC16203	Celastrol	34157-83-0
PC16200	Clasto-Lactacystin β-lactone	154226-60-5
PL10717	Dazcapistat	2221010-42-8
PL07789	Delanzomib	847499-27-8
PC16213	Dihydroeponemycin	126463-64-7
PC16204	Epoxomicin	134381-21-8
PL10736	GSK3494245	2080410-41-7
PC16256	HMB-Val-Ser-Leu-VE	862891-04-1