Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Mitochondrial Metabolism 相关产品（47）

货号	产品名	Cas
PL07343	(S)-Coriolic acid	29623-28-7
PL07329	Adjudin	252025-52-8
PL07319	Azemiglitazone	1133819-87-0
PL07303	CCI-006	292053-42-0
PL07344	CTPI-2	68003-38-3
PL07340	D-Histidine	351-50-8
PL07336	Devimistat	95809-78-2
PL07311	DX3-213B	2749555-66-4
PL07335	EPI-743	1213269-98-7
PL07317	ER-000444793	792957-74-5
PL07321	Fumarate hydratase-IN-1	1644060-37-6
PL07315	Fumarate hydratase-IN-2 sodium salt
PL07332	Gboxin	2101315-36-8
PL07330	Glyburide-d11	1189985-02-1
PL07331	Glyburide-d3	1219803-02-7
PL07313	GW604714X	853953-65-8
PL07337	IACS-010759	1570496-34-2
PL07320	IACS-010759 hydrochloride	1807523-99-4
PL07322	IM176OUT05	1643659-96-4
PL07342	IMT1	2304621-31-4