Antifolate

Antifolates agents work by antagonizing (blocking) the actions of folic acid (vitamin B9). Antifolates act specifically during DNA and RNA synthesis, exerting a cytotoxic effect during the S- phase of the cell cycle. Antifolates targeting folate metabolism played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases.

Folate (folic acid) cofactors are essential for the synthesis and metabolism of amino acids, consequently antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as Proguanil, Pyrimethamine and Trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. Major antifolate enzyme targets and exemplary antifolates that target these enzymes include: dihydrofolate reductase (DHFR), thymidylate synthase (TS), GARFTase and AICARFTase.

Antifolate 相关产品（27）

货号	产品名	Cas	产品描述
PL04061	Aminopterin	54-62-6
PL02907	Cycloguanil-d6
PL06178	DHFR-IN-3	137553-43-6
PL03679	Fanotaprim	2120282-75-7
PL04064	Lometrexol	106400-81-1
PL04065	Lometrexol disodium	120408-07-3
PL04066	Lometrexol hydrate	1435784-14-7
PL01636	LSN 3213128	1941211-99-9
PL01652	LY309887	127228-54-0
PL04062	Methotrexate	59-05-2	Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate也是一种免疫抑制剂和抗肿瘤剂，用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。
PL01656	Methotrexate metabolite-d3	1794780-00-9
PL03383	Methotrexate α-tert-butyl ester	79640-70-3
PL04063	Methotrexate-d3	432545-63-6
PL03050	Metoprine	7761-45-7
PL06063	Mirvetuximab	1453084-36-0
PL04071	Pelitrexol	446022-33-9
PL03710	Pemetrexed disodium hemipenta hydrate	357166-30-4
PL01496	Pralatrexate	146464-95-1
PL05423	Proguanil	500-92-5
PL05424	Proguanil-d4 (hydrochloride)	1189671-34-8