PC54583
|
(-)-WIN 55,212-3 (mesylate) |
131543-25-4 |
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors |
PC54591
|
1,24-dihydroxy Vitamin D3 (hydrate) |
93129-94-3 |
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity |
PC54564
|
19(R)-hydroxy Prostaglandin B2 |
211185-40-9 |
Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway |
PC54558
|
2-HBA |
131359-24-5 |
2-HBA 是一个有效的 NAD(P)H: 醌受体氧化还原酶 1 (NQO1) 诱导剂,也可以激活半胱天冬酶-3 (caspase-3) 和半胱天冬酶-10 (caspase-10)。 |
PC54595
|
5-trans Prostaglandin D2 |
2202725-84-4 |
Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Pharmaceutical Impurities||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway |
PC54585
|
Acetildenafil |
831217-01-7 |
Product Type|Biochemicals||Research Area |
PC54562
|
Atpenin A5 |
119509-24-9 |
Atpenin A5 是一种有效且高度特异性的 complex II 抑制剂,IC50 为 ~10 nM,且是一种有效的 mKATP 通道激动剂和心脏保护剂。 |
PC54584
|
Bosutinib |
380843-75-4 |
Bosutinib是一种口服Src/Abl酪氨酸激酶抑制剂,IC50分别为1.2 nM和1 nM。 |
PC54559
|
CDDO methyl ester |
218600-53-4 |
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) 是一种合成的三萜类化合物,具有潜在的抗肿瘤和抗炎活性,作为 Nrf2 通路的激活剂和 NF-κB 途径的抑制剂。 |
PC54575
|
CGP 36216 (hydrochloride) |
1781834-71-6 |
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience |
PC54570
|
cis-2-Decenoic Acid |
15790-91-7 |
Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Lipid Biochemistry|Fatty Acids |
PC54568
|
CP 945,598 (hydrochloride) |
686347-12-6 |
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors |
PC54592
|
CPTH2 (hydrochloride) |
2108899-91-6 |
Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation |
PC54572
|
Fingolimod |
162359-55-9 |
Fingolimod (FTY720 free base) 是一种 1-磷酸鞘氨醇 (sphingosine 1-phosphate,S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50 为 0.033 nM。Fingolimod 还是一种 pak1 激活剂,免疫抑制剂。 |
PC54586
|
GSK-J1 (sodium salt) |
1797832-71-3 |
Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation|Innate Immunity |
PC54587
|
GSK-J2 (sodium salt) |
2108665-15-0 |
Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Negative Controls||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation|Innate Immunity |
PC54589
|
GSK-J4 (hydrochloride) |
1797983-09-5 |
GSK-J4 hydrochloride 是一种有效的 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂,IC50 分别为 8.6 μM 和 6.6 μM。GSK-J4 hydrochloride 抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50 值为 9 μM。GSK-J4 hydrochloride 是 GSK-J1 的细胞通透性前药。 |
PC54590
|
GSK-J5 (hydrochloride) |
1797983-32-4 |
Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Negative Controls||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation|Innate Immunity |
PC54563
|
Hymeglusin |
29066-42-0 |
Hymeglusin 作为一种真菌 β-内酯 antibiotic,是一种 HMG-CoA 合酶抑制剂 (IC50 = 0.12 μM)。 Hymeglusin 共价修饰酶的活性 Cys129 残基。 |
PC54567
|
Irbesartan |
138402-11-6 |
Irbesartan (SR-47436) 是一种 Ang II 型 1 (AT1) 受体阻滞剂 (ARB),具有口服活性。Irbesartan 可放松血管,降低血压,增加血液和氧气供应到心脏。 Irbesartan 可用于高血压、心力衰竭和糖尿病肾病的研究。 |