Adenylate cyclase

Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.

Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca²⁺/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca²⁺-insensitive AC2, AC4, AC7; Group III: Gαi/Ca²⁺/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca²⁺/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.

Adenylate cyclase 相关产品（26）

货号	产品名	Cas
PC15108	1,9-Dideoxyforskolin	64657-18-7
PC15338	2',5'-dideoxy Adenosine	6698-26-6
PL02305	9-Cyclopentyladenine monomethanesulfonate	189639-09-6
PL04133	AC1-IN-1	2762422-55-7
PL05930	Angiopeptin TFA	2478421-60-0
PC15136	Bithionol	97-18-7
PL01304	CB-7921220	115453-99-1
PL05851	Cholera toxin	9012-63-9
PL05467	Fipexide	34161-24-5
PC14930	Forskolin.	66575-29-9
PC15327	Guanylyl Imidodiphosphate	148892-91-5
PL03657	Guanylyl imidodiphosphate lithium	64564-03-0
PC15247	KH 7	330676-02-3
PL01087	LRE1	1252362-53-0
PL05737	Lysipressin acetate	83968-49-4
PC15182	MDL 12330A hydrochloride	40297-09-4
PC15118	N6-methyladenosine (m6A).	1867-73-8
PL04019	NB001	686301-48-4
PC15185	NKH 477	138605-00-2
PC15272	NKY 80	299442-43-6