Guanylate Cyclase

Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells. Guanylyl cyclases signal via the production of the second messenger cGMP.

The GC family consists of particulate GC (pGC) and a nitric oxide-activated soluble GC (sGC). Seven pGC isoforms have yet been found (pGC-A to pGC-G). pGCs are activated by binding of peptide ligands to their extracellular domains. sGC is a receptor for endogenous and exogenous nitric oxide and is activated several-fold upon its binding, constituting a core enzyme in the nitric oxide signal transduction pathway. cGMP generated by sGC is an important second messenger that regulates activity of several enzymes triggering such important physiologic reactions as vasodilation, smooth muscle relaxation and platelet aggregation.

Guanylate Cyclase 相关产品（22）

货号	产品名	Cas
PL02356	(Rac)-MGV354	1852495-86-3
PC15348	Ataciguat	254877-67-3
PC15329	BAY 41-8543	256498-66-5
PL02162	BAY 60-2770	1027642-43-8
PL01624	CFM 1571 hydrochloride	1215548-30-3
PC14762	Cinaciguat	329773-35-5
PL03958	Cinaciguat hydrochloride	646995-35-9
PL05819	Guanylin(human) TFA
PL04746	Linaclotide	851199-59-2
PC15398	LY83583	91300-60-6
PL04077	Methylene Blue	61-73-4
PL05608	Methylene blue hydrate	122965-43-9
PL05504	Methylene blue trihydrate	7220-79-3
PL05983	MM 419447	1092457-78-7
PL01738	Olinciguat	1628732-62-6
PL01692	Plecanatide	467426-54-6
PL01693	Plecanatide acetate	1075732-84-1
PL01728	Praliciguat	1628730-49-3
PC14795	Riociguat	625115-55-1
PL01759	Runcaciguat	1402936-61-1