LXR

LXRs (Liver X Receptor α and β) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. LXRs are oxysterol-activated transcription factors that upregulate a suite of genes that together promote coordinated mobilization of excess cholesterol from cells and from the body. The LXRs, like other nuclear receptors, are anti-inflammatory, inhibiting signal-dependent induction of pro-inflammatory genes by nuclear factor-κB, activating protein-1, and other transcription factors.

LXRα is expressed predominately in some tissues, including the liver, kidney, macrophages, and adipose tissue. However, LXRβ is ubiquitously expressed. Activating LXRα (mainly expressed in liver) results in high triglyceride production, and growing evidence suggests that selective LXRβ agonists can reduce this side effect.

LXR 相关产品（28）

货号	产品名	Cas
PC15306	22(R)-羟基胆固醇	17954-98-2
PC15357	24(R)-hydroxy Cholesterol	27460-26-0
PC15339	24(S)-hydroxy Cholesterol	474-73-7
PC15409	24α-methyl Cholesterol	474-62-4
PC15378	25(S)-27-hydroxy Cholesterol	56845-83-1
PC61706	27-Hydroxycholesterol	20380-11-4
PC15302	Acetyl Podocarpic Acid Anhydride	344327-48-6
PL06809	AZ876	898800-26-5
PL06807	BMS-779788	918348-67-1
PL06803	DMHCA	79066-03-8
PC15201	Fexaramine	574013-66-4
PL06810	GSK2033	1221277-90-2
PL06806	GSK3987	264206-85-1
PC14771	GW3965	405911-09-3
PC14851	GW3965 HCl	405911-17-3
PL06804	Larsucosterol (trimethylamine)
PC14915	LXR-623	875787-07-8
PL06811	RGX-104	610318-54-2
PL06808	RGX-104 hydrochloride	610318-03-1
PL06805	Rovazolac	1454288-88-0