Insulin Receptor

Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B.

The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.

Insulin Receptor 相关产品（24）

货号	产品名	Cas
PL02094	AGL-2263	638213-98-6
PL04040	AVJ16
PL04493	Ceritinib-d7	1632484-77-5
PL02384	CMX-2043	910627-26-8
PL05982	DA-JC4	2315504-40-4
PL05970	GIP (1-30) amide, porcine TFA
PL05929	GIP (1-30) amide,human acetate
PL05971	GIP (3-42), human	1802086-25-4
PL05783	GIP, human TFA
PL03112	GSK1838705A	1116235-97-2
PL01514	GSK1904529A	1089283-49-7
PL01697	Insulin aspart	116094-23-6
PL01695	Insulin degludec	844439-96-9
PL01689	Insulin glargine	160337-95-1
PL01797	Insulin glulisine	207748-29-6
PL05818	Insulin(cattle)	11070-73-8
PL02255	MID-1	312608-54-1
PL01090	MSDC 0160	146062-49-9
PL04137	NT219	1198078-60-2
PL01359	NVP-ADW742	475488-23-4