IRAK

Interleukin-1 receptor-associated kinases (IRAKs), are serine/threonine kinases, play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways. The four different IRAK-like molecules have been identified: two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. All IRAKs mediate activation of nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.

Toll-like receptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4). IRAK-1 and IRAK-2, known to form Myddosomes with MyD88-IRAK-4, mediate TLR7-induced TAK1-dependent NF-κB activation. IRAK-M is known to function as a negative regulator that prevents the dissociation of IRAKs from MyD88, thereby inhibiting downstream signalling.

IRAK 相关产品（25）

货号	产品名	Cas
PL04854	AS2444697	1287665-60-4
PL01871	AZ1495	2196204-23-4
PL04205	Edecesertib	2408839-73-4
PL03451	Emavusertib	1801344-14-8
PL03432	HS-243	848249-10-5
PL04192	HS-276	2767422-72-8
PL03246	HS271	2410393-15-4
PC16028	IRAK inhibitor 1	1042224-63-4
PC16029	IRAK inhibitor 2	928333-30-6
PC16030	IRAK inhibitor 3	1012343-93-9
PC16031	IRAK inhibitor 4	1012104-68-5
PL03309	IRAK inhibitor 4 trans
PC16032	IRAK inhibitor 6	1042672-97-8
PC16033	IRAK-1-4 Inhibitor I	509093-47-4
PL05140	IRAK-4 protein kinase inhibitor 2	301675-24-1
PL01308	IRAK4-IN-1	1820787-94-7
PL02181	IRAK4-IN-4	1850276-58-2
PL03121	IRAK4-IN-6	2454244-02-9
PL01801	IRAK4-IN-7	1801343-74-7
PL01371	JH-X-119-01	2227368-54-7