c-FMS

c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. c-FMS is the cell surface receptor for IL-34 and CSF1. c-FMS has important roles in haematopoiesis, regulation of proliferation, cell survival and maturation of microglia and monocytes, as well as in controlling the overall immune response.

c-FMS is specifically expressed in osteoclasts and myelomonocytic-lineage cells, such as monocytes and macrophages, and the activation of c-FMS signaling promotes the proliferation or differentiation of these cells. It also promotes the production of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL6).

c-FMS 相关产品（30）

货号	产品名	Cas
PC54725	ABT-869	796967-16-3
PL02330	AZD7507	1041852-85-0
PL03325	BPR1R024	2503015-75-4
PL04842	c-Fms-IN-1	885703-64-0
PL02812	c-Fms-IN-10	1527517-50-5
PL04255	c-Fms-IN-13	885704-58-5
PL04841	c-Fms-IN-2	791587-67-2
PL03169	c-Fms-IN-3	885704-21-2
PL02417	c-Fms-IN-8	1255303-58-2
PL02044	cFMS Receptor Inhibitor II	959860-85-6
PL02045	cFMS Receptor Inhibitor IV	959626-45-0
PL02675	Chiauranib	1256349-48-0
PL01279	CSF1R-IN-1	2095849-04-8
PL03894	CSF1R-IN-3	2760584-90-3
PL01745	Edicotinib	1142363-52-7
PL01961	Elzovantinib	2271119-26-5
PL06067	Emactuzumab	1448221-67-7
PL01240	GENZ-882706	2070864-35-4
PL01774	GW2580	870483-87-7
PC16035	Ki20227	623142-96-1