FLT3

FLT3 (Fms-like tyrosine kinase 3, CD135) is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. FLT3 is the receptor for the cytokine Flt3 ligand (FLT3L). FLT-3 is expressed on the surface of many hematopoietic progenitor cells. Signalling of FLT3 is important for the normal development of haematopoietic stem cells and progenitor cells. The FLT3 gene is one of the most frequently mutated genes in acute myeloid leukemia (AML). Besides, high levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. These high levels may be associated with worse prognosis. Signaling through FLT3 plays a role in cell survival, proliferation, and differentiation. FLT3 is important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells. Two cytokines that down modulate FLT3 activity are TNF-Alpha and TGF-Beta.

FLT3 相关产品（67）

货号	产品名	Cas
PL04372	(E/Z)-Zotiraciclib citrate
PL04371	(E/Z)-Zotiraciclib hydrochloride	1321626-25-8
PL01658	3-Hydroxy Midostaurin	179237-49-1
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PC16115	5'-Fluoroindirubinoxime	861214-33-7
PL03433	AC710	1351522-04-7
PL02365	AKN-028 acetate
PL04557	AMG 925	1401033-86-0
PL04558	AMG 925 HCl	1401034-19-2
PL01338	Amuvatinib	850879-09-3
PC16018	AST 487	630124-46-8
PL04316	ATH686	853299-52-2
PL04785	AZD2932	883986-34-3
PL03461	BPR1J-097 Hydrochloride
PL01138	BPR1K871	2443767-35-7
PL03108	Cabozantinib-d6	1802168-46-2
PL04781	CCT241736	1402709-93-6
PL03167	Cenisertib	871357-89-0
PL03306	CHIR-124	405168-58-3
PL01340	Dovitinib lactate	692737-80-7