FAK

FAK (Focal Adhesion Kinase or PTK2) is a non-receptor and non-membrane associated protein tyrosine kinase that is activated at the sites of cell-matrix adhesions and integrin clustering by auto-phosphorylation (at Tyr397), Src, and other tyrosine kinases. FAK mediates integrin-based cell signaling by transferring signals regulating cell migration, adhesion, and survival from the extracellular matrix to the cytoplasm.

FAK is overexpressed in many tumors, including those derived from the head and neck, colon, breast, prostate, liver, and thyroid. Furthermore, FAK overexpression is highly correlated with an invasive phenotype in these tumors. Inhibition of FAK signaling by overexpression of dominant-negative fragments of FAK reduces invasion of glioblastomas and ovarian cancer cells. FAK therefore represents an important target for the development of anti-neoplastic and anti-metastatic drugs.

FAK 相关产品（24）

货号	产品名	Cas
PL04422	ALK inhibitor 1	761436-81-1
PL04300	AT-533	908112-37-8
PL01935	BI-3663	2341740-84-7
PL02689	BI-4464	1227948-02-8
PL01744	Conteltinib	1384860-29-0
PL02572	Defactinib	1073154-85-4
PL02574	Defactinib hydrochloride	1073160-26-5
PC16159	FAK Inhibitor 14	4506-66-5
PL02942	FAK inhibitor 2	2354405-14-2
PL04248	FAK-IN-7	19948-85-7
PL03290	GSK215	2743427-26-9
PL01082	GSK2256098	1224887-10-8
PL02566	Ifebemtinib	1227948-82-4
PL04879	NAMI-A	201653-76-1
PL04112	Narmafotinib	1393653-34-3
PC16071	PF-00562271	939791-38-5
PC16091	PF-573228	869288-64-2
PL03812	PND-1186	1061353-68-1
PL03813	PND-1186 hydrochloride	1356154-94-3
PL02413	PROTAC FAK degrader 1	2301916-69-6