Okadaic acid(solution)|78111-17-8|(冈田酸)-陌孚医药/Medlife

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Okadaic acid(solution) (Synonyms: 冈田酸)

目录号: PC10107 纯度: ≥98%

CAS No. :78111-17-8

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中文名称	Okadaic acid(solution)
中文别名	冈田酸(软海绵酸);35-去甲基鳍藻毒素 1;冈田(软海绵)酸;冈田[软海绵]酸;冈田酸;冈田酸游离酸 (黑海棉酸);黑海棉酸;Okadaic acid,软海绵酸,黑海绵酸;大田软海绵酸;黑海绵酸Okadaic acid(OA);软海绵酸;软海绵酸,冈田酸,黑海绵酸Okadaic acid
英文名称	Okadaic acid(solution)
英文别名	1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-,(aR,2S,5R,6R,8S)-;Okadaic Acid;1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-meth...;1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS);Blue mussel, homogenized (Okadaic acid);Okadaic acid (high purity);Okadaic Acid (NSC 677083, Acanthifolicin,Halochondrine A);Okadaic acid solution;9,10-deepithio-9,10-didehydroacanthifolicin;Ocadaic Acid;okadaic acd;OKADAICACID,HIGHPURITY;Okadic acid;35-Demethyl-DTX 1;35-Demethyldinophysistoxin 1;NSC 677083;OA;(2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4As,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-m
Cas No.	78111-17-8
分子式	C₄₄H₆₈O₁₃
分子量	805.00
包装储存	Solution, -20°C, 2 years

生物活性

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC₅₀=0.1-0.3 nM), and inhibits PP1 (IC₅₀=15-50 nM), PP3 (IC₅₀=3.7-4 nM), PP4 (IC₅₀=0.1 nM), PP5 (IC₅₀=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation.

性状

Liquid

IC50 & Target[1][2]

PP1

15-50 nM (IC₅₀)

PP2A

0.1-0.3 nM (IC₅₀)

PP3

3.7-4 nM (IC₅₀)

PP4

0.1 nM (IC₅₀)

PP5

3.5 nM (IC₅₀)

PP2B

~4000 nM (IC₅₀)

PP7

＞1000 nM (IC₅₀)

体外研究(In Vitro)

Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells.
Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	AGS, MNK-45 and Caco 2 cell lines
Concentration:	0-100 nM
Incubation Time:	24 h or 48 h
Result:	Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.

体内研究(In Vivo)

Okadaic acid (100 μM; injected unilaterally to the lateral amygdala) induces Tau phosphorylation and protein aggregation in anatomically distinct brain regions 24 h post-injection.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Solution, -20°C, 2 years

结构分类