Bryostatin 1|83314-01-6|(苔藓抑素1)-陌孚医药/Medlife

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Bryostatin 1 (Synonyms: 苔藓抑素1)

目录号: PC15980 纯度: ≥98%

CAS No. :83314-01-6

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中文名称

Bryostatin 1

中文别名

藓苔抑制素1

英文名称

Bryostatin 1

英文别名

2,4-Octadienoic acid,(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-ylester, (2E,4E)-;2,4-Octadienoic acid,(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-t...;BRYOSTATIN 1;Bryostatin 1,(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-;BRYO 1;BRYOSTATIN;bryostatin1,0;bryostatine-1

Cas No.

83314-01-6

分子式

C₄₇H₆₈O₁₇

分子量

905.03

包装储存

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties.

性状

Solid

IC50 & Target[1][2]

HIV-1

体外研究(In Vitro)

Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation .
The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed.
Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via toll-like receptor 4 (TLR4) through the MyD88-independent pathway, which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4 T-helper (Th) lymphocytes into Th2 versus Th1 effector cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	HT22 cells
Concentration:	1 μM
Incubation Time:	5 minutes
Result:	Caused Munc13-1 to transfer to the membrane fraction.

体内研究(In Vivo)

Bryostatin 1 (30 μg/kg; intraperitoneal injection; 3 d per week; for 2 weeks; C57BL/6J mice) treatment abolishes the onset of EAE.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6J mice (8-12-week-old) with MOG_35-55
Dosage:	30 μg/kg
Administration:	Intraperitoneal injection; 3 d per week; for 2 weeks
Result:	Abolished the onset of experimental autoimmune encephalomyelitis (EAE).