RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor.

Solid

IC50: ALK5 autophosphorylation (4 nM)

RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs).
RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs.
RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

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  [3]. Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10(5):1505-1521.  [Information]