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Paeoniflorin (Synonyms: 芍药苷; Peoniflorin)
目录号: PC13465 纯度: ≥98%
CAS No. :23180-57-6
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中文名称
Paeoniflorin
中文别名
芍药甙;芍药苷;芍药苷提取物;Paeoniflorin 芍药甙;WAKO164-21731芍药甙;白芍甙;白芍苷 白芍提取物 白芍苷White Peony Root Extract;白芍提取物;赤芍提取物;芍药;芍药甙 白芍提取物;芍药甙Paeoniflorin;芍药苷 Paeoniflorin;芍药苷 标准品;芍药苷,Paeoniflorin,植物提取物,标准品,对照品;芍药苷标准品(JP);芍药提取物
英文名称
Paeoniflorin
英文别名
β-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-;Paeoniflorin;PAEONIFLORIN(P);Peoniflorin;Delmacinone;PACLITAXEL;Paeonia lactiflora P,E,;Paeonia moutan;paeoniflorine;Paeoniflorm;Paeony root;NSC 178886;5beta-[(Benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1alpha(2H)-yl-beta-D-glucopyranoside;[ "" ];Radix Paeoniae Alba Extract.;N1718;[(1R,2S,3R,5R,6R,8S)-6-Hydroxy-8-methyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2;[(1R,2S,3R,5R,6R,8S)-6-Hydroxy-8-methyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate;21AIQ4EV64;C23H28O11;((2S,2aR,2a1S,3aR,4R,5aR)-4-Hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl benzoate;paeoniflorin;;Peoniflorin;;NSC178886;Paeoniflorin, analytical standard;Paeoniflorin, >
Cas No.
23180-57-6
分子式
C23H28O11
分子量
480.46
包装储存
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
生物活性

Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.

性状

Solid

体外研究(In Vitro)

Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line: HeLa and IMR-32 cells
Concentration: 80 μg/mL
Incubation Time: 4, 8, 12, 16, and 24 hours
Result: Promoted the phosphorylation of HSF1.
体内研究(In Vivo)

Paeoniflorin (intradermal injection; 25 and 100mg/kg; once daily; 20 days) shows favorable effects on experimental arthritis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats with collagen induced arthritis
Dosage: 25 and 100mg/kg
Administration: Intradermal injection; 25 and 100mg/kg; once daily; 20 days
Result: Decreased arthritis score, relieved ankle and paw swelling, improved spleen istopathology, decreased the levels of IgA, IgM, IgG and anti-CII antibody.
运输条件

Room temperature or refrigerated transportation.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
ClinicalTrial
结构分类
来源
参考文献
溶解度数据
体外研究: 

DMSO : 100 mg/mL (208.13 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (208.13 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0813 mL 10.4067 mL 20.8134 mL
5 mM 0.4163 mL 2.0813 mL 4.1627 mL
10 mM 0.2081 mL 1.0407 mL 2.0813 mL
*

产品不同,其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液;配成溶液后,建议分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,建议在 6 个月内使用,-20°C 储存时,建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    建议依照次序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH?O 中,得到澄清透明的生理盐水溶液
  • 2.

    建议依照次序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.20 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    建议依照次序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (5.20 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2