PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki values of 5 nM and 1.5 nM, and exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.
性状
Solid
IC50 & Target[1][2]
p110α
910 nM (IC50)
p110β
600 nM (IC50)
p110δ
5 nM (IC50)
体外研究(In Vitro)
PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.