(-)-Xestospongin C|88903-69-9|((-)-Xestospongin C)-陌孚医药/Medlife

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(-)-Xestospongin C (Synonyms: (-)-Xestospongin C)

目录号: PC12186 纯度: ≥98%

CAS No. :88903-69-9

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中文名称

(-)-Xestospongin C

中文别名

光溜海绵素C

英文名称

(-)-Xestospongin C

英文别名

5H,17H-1,23:11,13-Diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine,eicosahydro-, (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-;(-)-Xestospongin C;5H,17H-1,23:11,13-Diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine,eicosahyd...;XESTOSPONGIN C;Xestospongin C（Xec,Araguspongine E）;XESTOSPONGIN C,FOR BIOCHEMISTRY;(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine;[1R-(1R*,4AR*,11R*,12AS*,13S*,16AS*,23R*,24AS*)]-EICOSAHYDRO-5H,17H-1,23:11,13-DIETHANO-2H,14H-[1,11]DIOXACYCLOEICOSINO[2,3-B:12,13-B']DIPYRIDINE;ARGUSPONGINE E;XEC;XESTOSPONGIN

Cas No.

88903-69-9

分子式

C₂₈H₅₀N₂O₂

分子量

446.71

包装储存

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca release from cerebellar microsomes with an IC₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca signaling in neuronal and nonneuronal cells.

性状

Viscous liquid

IC50 & Target[1][2]

IP3R

体外研究(In Vitro)

Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ_1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%).
Xestospongin C (10 μM; 1 h before Aβ) and Aβ_1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca changes, as well as a significant interaction in primary cultured hippocampal neurons.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimers disease.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

来源

a marine sponge, Xestospongia sp.

参考文献

[1]. Wang ZJ, et al. Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimers Disease. J Alzheimers Dis. 2019;72(4):1217-1231. [Information]

[2]. Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep;19(3):723-33. doi: 10.1016/s0896-6273(00)80384-0. PMID: 9331361. [Information]

[3]. Castonguay A, et al. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. Cell Calcium. 2002;32(1):39-47. [Information]

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