Z-Ile-Leu-aldehyde|161710-10-7|(Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)-陌孚医药/Medlife

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Z-Ile-Leu-aldehyde (Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

目录号: PC15859 纯度: ≥98%

CAS No. :161710-10-7

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PC15859-10mg	10mg	¥4655.00	请登录
PC15859-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥3822.00	请登录

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中文名称

Z-Ile-Leu-aldehyde

中文别名

gamma-分泌酶抑制剂 XII

英文名称

Z-Ile-Leu-aldehyde

英文别名

Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate;Z-ILE-LEU-ALDEHYDE;Z-IL-CHO;GAMMA-SECRETASE INHIBITOR XII;GSI-XII;γ-Secretase inhibitor XII;γ-Secretase inhibitor XII (GSI-XII)

Cas No.

161710-10-7

分子式

C₂₀H₃₀N₂O₄

分子量

362.46

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch.

性状

Solid

体外研究(In Vitro)

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 体外研究 polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCRsup>[1]

Cell Line:	CD4 T cells from C57BL/6 mice.
Concentration:	25 μM.
Incubation Time:	24, 48, 72 hours.
Result:	DownregulateD ROR?t and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line:	MOPC315.BM cells.
Concentration:	0, 12, 15 μM.
Incubation Time:	24-48?h hours.
Result:	Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究(In Vivo)

Z-Ile-Leu-aldehyde (GSI XII, 10?mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MOPC315.BM mouse model.
Dosage:	10?mg/kg.
Administration:	Intraperitoneally either for 14 days.
Result:	Reduces myeloma-specific paraprotein levels in the MOPC315.BM model. Diminished osteolytic lesions in the MOPC315.BM mice.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.

[2]. Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217. [Information]

溶解度数据

体外研究:

DMSO : ≥ 41 mg/mL (113.12 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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