Adenosine 5'-monophosphate monohydrate.|18422-05-4|(5'-AMP monohydrate)-陌孚医药/Medlife

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Adenosine 5'-monophosphate monohydrate. (Synonyms: 5'-AMP monohydrate)

目录号: PC19101 纯度: ≥98%

CAS No. :18422-05-4

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中文名称

Adenosine 5'-monophosphate monohydrate.

中文别名

腺苷-5'-单磷酸一水合物;腺苷-5-磷酸;腺苷-5'-磷酸;腺苷-5'-磷酸(一水);3,4-二甲氧基苯丙胺;5’-腺苷单磷酸一水合物;腺苷-5"-单磷酸一水合物;腺苷-5’-单磷酸一水合物;腺苷-5’-磷酸;腺苷-5'-单磷酸一水合物AMP(酵母来源);腺苷-5''-单磷酸一水合物;腺苷-5-单磷酸一水合物;腺苷-5''-磷酸;5’-磷酸腺苷;5'-一磷酸腺苷,不含酸,来源于酵母;腺苷-5'-单磷酸水合物;5′-腺苷酸;肌肉腺苷酸;5'-磷酸腺苷,AMP;腺苷-5`-单磷酸水合物;腺苷-5'-磷酸一水合物;腺苷-5'-单磷酸一水;腺苷-5'-磷酸(+4℃);腺苷-5'-磷酸一水物

英文名称

Adenosine monophosphate

英文别名

Adenosine 5'-monophosphate monohydrate;5'-AMP H2O;5'-AMP MONOHYDRATE;ADENOSINE 5'-MONOPHOSPHORIC ACID MONOHYDRATE;ADENYLIC ACID MONOHYDRATE;A-5'-P;Adenosine-5'-monophosphate;5'-AMP;5'-AMPH2;Adenosine 5′-monophosphate monohydrate;AMP monohydrate;AMP.H2O;5′-AMP;A-5′-P;AMP;Adenosine-5’-phospho;AMP monohydrate;5'-AMP=Adenylicacid;adenosine 5'-monophosphate;5'-adenylic acid;Adenosine monophosphate;adenosine phosphate;adenylic acid;adenosine 5'-phosphate;Phosphaden;adenylate;Phosphentaside;Adenovite;Phosaden;Cardiomone;Lycedan;Vitamin B8;My-B-Den;Myoston;Ergadenylic acid;Monophosphadenine;Muscle adenylic acid;Muskeladenylsaeure;5'-adenosine monophosphate;AMP (nucleotide);Adenosine 5'-(dihydrogen phosphate);Adenosine 5'-phosphoric acid;Adenosini phosphas;Adenosine-5-monophosphor

Cas No.

18422-05-4

分子式

C₁₀N₅O₈PH₁₆

分子量

365.24

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Adenosine 5-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite

HSV-1

HSV-2

Human Endogenous Metabolite

体外研究(In Vitro)

Adenosine 5-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400?μM in RAW264.7 cells. Adenosine 5-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400?μM, Adenosine 5-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

C57BL/6J mice treated with Adenosine 5-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8?h) and 33.3% (24?h), whereas survival rate in Adenosine 5-monophosphate monohydrate-treated mice (n=15) is 100% (8?h) and 93.3% (24?h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5-monophosphate monohydrate group.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

Ketones, Aldehydes, Acids

参考文献

[1]. Rittiner JE, et al. AMP is an adenosine A1 receptor agonist. J Biol Chem. 2012 Feb 17;287(8):5301-9. [Information]

[2]. Zhan Y, et al. Adenosine 5-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice. Cell Death Dis. 2014 Jan 9;5:e985. [Information]

[3]. Ayisi NK, et al. Comparison of the antiviral effects of 5-methoxymethyldeoxyuridine-5-monophosphate with adenine arabinoside-5-monophosphate. Antiviral Res. 1983 Sep;3(3):161-74. [Information]

溶解度数据

体外研究:

H₂O : 5 mg/mL (13.69 mM; Need ultrasonic and warming)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7379 mL	13.6896 mL	27.3793 mL
5 mM	0.5476 mL	2.7379 mL	5.4759 mL
10 mM	0.2738 mL	1.3690 mL	2.7379 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 5.26 mg/mL (14.40 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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