Novobiocin Sodium|1476-53-5|(Albamycin sodium; Cathomycin sodium)-陌孚医药/Medlife

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Novobiocin Sodium (Synonyms: Albamycin sodium; Cathomycin sodium)

目录号: PC11716 纯度: ≥98%

CAS No. :1476-53-5

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PC11716-50mg	50mg	¥490.00	请登录
PC11716-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥490.00	请登录

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中文名称	Novobiocin Sodium
中文别名	新生霉素钠;2-氟-6-(三氟甲基)苯甲酰胺;WAKO148-09171氧乐果-D6标准品;新生霉素;新生霉素钠盐;新生霉素标准品;新生霉素纳;新生霉素钠盐标准品;新生霉素一钠盐;氧乐果-D6;新戊福林;新生霉素氯化钠;新生霉素一钠、新戊福林、氧乐果-D6;NOVOBIOCIN SODIUM SALT 新生霉素;新生霉素钠盐;新生霉素钠盐90%;新生霉素钠盐(+4℃)
英文名称	Novobiocin Sodium
英文别名	Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1);Novobiocin Sodium Salt;Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]...;Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-;Novobiocin Sodium;Novobiocin Sodium (U-6591);Novobiocin Sodium Sa;Albamycin;Cathomycin;Crystallinic acid MonosodiuM salt;Novobiocin;Robicina;Albamycin sodium;Cathomycin sodium;Cathomycin sodium lyovac;Monosodium novobiocin;NSC 2382;Novobiocin monosodium;U-6591;Albadry;Vulcamycin;STREPTONIVICIN;Albycin sodium;Sodiumalbamycin;Albamycinsodium;BCP14372;Sodium;4-[[7-[(3S,5R)-4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-4-hydroxy-8-methy
Cas No.	1476-53-5
分子式	C₃₁H₃₅N₂NaO₁₁
分子量	634.61
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.

性状

Solid

IC50 & Target[1][2]

β-lactam

HSP90

体外研究(In Vitro)

Novobiocin sodium (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.
Novobiocin sodium (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.
Novobiocin sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	K562, HL60, Mutz-2 cells
Concentration:	0.3 mM
Incubation Time:	48 hours
Result:	Decreased caspase-3/7 activity in K562, HL60, Mutz-2 cells.

体内研究(In Vivo)

Novobiocin sodium (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))
Dosage:	25, 50, 100, 200 mg/kg
Administration:	S.c.; given at 1, 5, 24 and 48 h after infection
Result:	Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

结构分类

来源

Streptomyces niveus

参考文献

[1]. Marcu MG, et al. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 2000 Nov 24;275(47):37181-6. [Information]

[2]. Ali-Osman F, et al. Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells. Cancer Res. 1993 Dec 1;53(23):5663-8. [Information]

[3]. Rodríguez-Cerrato V, et al. Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci. Int J Antimicrob Agents. 2010 Jun;35(6):544-9. [Information]

[4]. Eder JP, et al. A phase I clinical trial of novobiocin, a modulator of alkylating agent cytotoxicity. Cancer Res. 1991 Jan 15;51(2):510-3. [Information]

[5]. Bhatia S, et al. Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.Blood. 2018 Jul 19;132(3):307-320. [Information]

[6]. Smee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19(3):115-24. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (78.79 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (47.27 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5758 mL	7.8789 mL	15.7577 mL
5 mM	0.3152 mL	1.5758 mL	3.1515 mL
10 mM	0.1576 mL	0.7879 mL	1.5758 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (157.58 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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