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Latrunculin B(solution) (Synonyms: 红海海绵素 B)

目录号: PC18831 纯度: ≥98%

CAS No. :76343-94-7

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中文名称

Latrunculin B(solution)

中文别名

甲基伸腈基羧酸盐;红海海绵素 B

英文名称

Latrunculin B(solution)

英文别名

2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)-;2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-;LATRUNCULIN B;LAT-B;LATRUNCULIN B,LATRUNCULIA MAGNIFICA;LatrunculinBfromLutrunculiamagnifica;NSC 339663

Cas No.

76343-94-7

分子式

C₂₀NO₅SH₂₉

分子量

395.51

包装储存

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.

性状

Oil

体外研究(In Vitro)

Latrunculin B displays growth inhibition of HeLa cells with an IC₅₀ value of 1.4 μM.
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na current, L-type Ca current, Na/Ca exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K current and ultra-rapid delayed rectifier K current, but increases the delayed rectifier K current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca transient and sarcoplasmic reticulum Ca content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

来源

Red Sea sponge

参考文献

[1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214. [Information]

[2]. Yen-Yu Lu, et al. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. [Information]

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