柄曲霉素|10048-13-2|(甾体半胱氨酸)-陌孚医药/Medlife

您当前的位置：

柄曲霉素 (Synonyms: 甾体半胱氨酸)

目录号: PC18088 纯度: ≥98%

CAS No. :10048-13-2

商品编号	规格	价格	会员价
PC18088-500μg	500μg	¥528.00	请登录
PC18088-1mg	1mg	¥739.00	请登录
PC18088-10mg	10mg	¥4235.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	柄曲霉素
中文别名	柄曲菌素;柄曲霉素;柄曲霉素溶液;杂色曲霉素;柄曲霉素标准品;柄曲霉素标准品 Sterigmatocystin;3a,12c-二氢-8-羟基-6-甲氧基-7H-糠醛[3′,2′:4,5]呋[2,3-c]呫吨-7-酮;3a,12c-二氢-8-羟基-6-甲氧基-7H-糠醛[3′,2′:4,5]呋[2,3-c]-呫吨-7-酮
英文名称	7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)-
英文别名	7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)-;Sterigmatocystin;Sterigmatocystin solution;STERIGMATOCYSTIN(RG);Sterigmatocystine;Sterigmatocystin, Aspergillus Versicolor;NSC 201423;NSC 204985;(3aR,12cS)-3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one;[ "" ]
Cas No.	10048-13-2
分子式	C₁₈O₆H₁₂
分子量	324.28
包装储存	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性

Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite

Human Endogenous Metabolite

体外研究(In Vitro)

Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

结构分类

来源

Aspergillus versicolor

参考文献

[1]. Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16(4):224-31. [Information]

[2]. Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30(4):589-91. [Information]

[3]. Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42(4):1645-1656. [Information]

[4]. Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells 体外研究. PLoS One. 2013 May 21;8(5):e65044. [Information]

溶解度数据

体外研究:

DMSO : 25 mg/mL (77.09 mM; ultrasonic and warming and heat to 80°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0838 mL	15.4188 mL	30.8375 mL
5 mM	0.6168 mL	3.0838 mL	6.1675 mL
10 mM	0.3084 mL	1.5419 mL	3.0838 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation