Orexin A (human, rat, mouse)|205640-90-0|(Hypocretin-1 (human, rat, mouse))-陌孚医药/Medlife

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Orexin A (human, rat, mouse) (Synonyms: Hypocretin-1 (human, rat, mouse))

目录号: PC10836 纯度: ≥98%

CAS No. :205640-90-0

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中文名称

Orexin A (human, rat, mouse)

中文别名

牛食欲素 A;食欲素

英文名称

Orexin A (human, rat, mouse)

英文别名

OREXIN A (HUMAN, BOVINE, CANINE, MOUSE, OVINE, PORCINE, RAT);Orexin A;Orexin A (bovine, human, mouse, rat);Orexin A (human, mouse, rat);OREXIN A (HUMAN, RAT, MOUSE);Orexin-A (Human);Baicalin-7-glucoside;HYPOCRETIN;Hypocretin 1;M.W. 3561.12 C152H243N47O44S4;OREXIN A,BOVINE,HUMAN,MOUSE,RAT;OREXINS OREXIN A HUMAN,RAT,MOUSE;Oroxin A

Cas No.

205640-90-0

分子式

C₁₅₂H₂₄₇N₄₇O₄₄S₄

分子量

3565.14

包装储存

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.

性状

Solid

IC50 & Target[1][2]

OX₁ Receptor

体外研究(In Vitro)

Orexin A (human, rat, mouse) has high affinity for OX1R, with 38 nM IC₅₀ and 34 nM EC₅₀ values in the the [Ca]i transient assay.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Orexin A (human, rat, mouse) (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively.
Orexin A (human, rat, mouse) (3, 10 and 30 mg/kg; i.v.) was given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice (mouse carrageenan-induced thermal hyperalgesia test)
Dosage:	3, 10 and 30 mg/kg
Administration:	i.v.; 5 min pre-test
Result:	Significantly increased the latency to response at 10 and 30 mg/kg.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SequenceShortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Solvent&Solubility

体外研究:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Information]

[2]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90. [Information]

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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