Acetyl-Calpastatin (184-210) (human)|123714-50-1|-陌孚医药/Medlife

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Acetyl-Calpastatin (184-210) (human)

目录号: PC15683 纯度: ≥98%

CAS No. :123714-50-1

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中文名称	Acetyl-Calpastatin (184-210) (human)
中文别名	乙酰钙蛋白酶抑制蛋白(184-210)(人);乙酰钙蛋白酶抑制蛋白(184-210);乙酰钙蛋白酶抑制蛋白
英文名称	Acetyl-Calpastatin (184-210) (human)
英文别名	AC-ASP-PRO-MET-SER-SER-THR-TYR-ILE-GLU-GLU-LEU-GLY-LYS-ARG-GLU-VAL-THR-ILE-PRO-PRO-LYS-TYR-ARG-GLU-LEU-LEU-ALA-NH2;Acetyl-Calpastatin (184-210) (human);CS PEPTIDE;CS PEPTIDE HUMAN;CALPASTATIN PEPTIDE;ACETYL-CALPASTATIN HUMAN;AC-CALPASTATIN (184-210) (HUMAN);AC-DPMSSTYIEELGKREVTIPPKYRELLA-NH2;ACETYL-SPERM BS-17 COMPONENT (184-210) (HUMAN);ACETYL-CALPAIN INHIBITOR FRAGMENT (184-210) (HUMAN);Acetyl-SperM BS-17 CoMponent (184-210) (huMan), Acetyl-Calpain Inhibitor FragMent (184-210) (huMan)
Cas No.	123714-50-1
分子式	C₁₄₂H₂₃₀N₃₆O₄₄S
分子量	3177.63
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性

Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with K_i values of 0.2 nM and 6 μM for μ-calpain and cathepsin L, respectively.

体外研究(In Vitro)

Acetyl-Calpastatin(184-210)(human) (peptide 1; 12.5-100 μM) inhibits calpains in LCLC 103H cells with an IC₅₀ of 27 μM.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

SequenceShortening

Ac-DPMSSTYIEELGKREVTIPPKYRELLA-NH2

Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Solvent&Solubility

体外研究:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3. [Information]

[2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355. [Information]

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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