★L-Lysine hydrochloride|657-27-2|(盐酸赖氨酸)-陌孚医药/Medlife

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★L-Lysine hydrochloride (Synonyms: 盐酸赖氨酸)

目录号: PC18911 纯度: ≥98%

CAS No. :657-27-2

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中文名称	★L-Lysine hydrochloride
中文别名	2,6-二氨基己酸盐酸盐;L-盐酸赖氨酸;赖氨酸盐酸盐;盐酸L-赖氨酸;赖氨酸 HCL;L-赖氨酸单盐酸盐;(S)-2,6-二氨基己酸盐酸盐;L-赖氨酸盐酸盐;L-(+)-赖氨酸单盐酸盐;L-赖氨酸;L-赖氨酸盐酸盐 USP标准品;L-赖氨酸盐酸盐标准品;L-赖氨酸盐酸盐(L-Lysine hydrochloride);L-赖氨酸一水盐酸盐;L-鸟氨酸盐酸盐;碱化可可粉;可可粉;盐酸赖氨酸;盐酸赖氨酸 EP标准品;6-二氨基已酸;L-赖氨酸二盐酸盐;L-赖氨酸碱;L-盐酸赖氨酸,2,6-二氨基己酸盐酸盐;(S)-2,6-二氨基己酸单盐酸盐;L-赖氨酸单盐酸盐;湖北L-赖氨酸盐酸盐生产厂家
英文名称	L-Lysine hydrochloride
英文别名	L-Lysine hydrochloride;L(+)-2,6-Diaminocaproic acid;(S)-2,6-Diaminohexanoic acid monohydrochloride;H-Lys-OH.HCl;L(+)-LYS hydrochloride;L-Lysine monohydrochloride;L-lysine hcl solution sterilefiltered cell cultu;lysine hydrochloride;H-Lys-OHHCl;L-Lysine HCl;L(+)-2,6-Diaminohexanoic acid;L(+)LYSINE MONOCHLORHYDRATE;L-(+)-Lysine Monohydrochloride;L-Lysine monohydrocholoride;(S)-2,6-Diaminohexanoic acid hydrochloride;CultureSure L-Lysine Hydrochloride, Animal-derived-free;H-Lys-OH · HCl;H-Lys-OH•HCl;L-LYSINE-2,3,3,4,4,5,5,6,6-D9 HCL;LYSINE HCL, L-(P);LYSINE HCL, L-(RG);PARAGOS 420321;anhydrous L-lysine monohydrochloride;H-Lys-OH hydrochloride;L-2;L-LYS HCL;L-Lysine;L-Lysine base;LYS,HCL;LYSINE HCL;LYSINE-L HCL;(2S)-2,6-Diaminohexanoic acid hydrochloride;L(+)-2,6-Diaminocaproic acid hydrochloride;L(+)-2,6-Diaminohexanoic acid hydrochloride;H-Lys-OH·HCl;湖北L-赖氨酸盐酸盐生产厂家;L-Lysine, monohydrochloride;Lyamine;Darvyl;Lysion;L-Gen;Enisyl;Lysine, monohydrochloride, L-;Lysine hydrochloride (VAN);L-Lysine hydrochloride (VAN);L-Lysine, hydrochloride (1:?);JNJ23Q2COM;l(+)-l
Cas No.	657-27-2
分子式	C₆H₁₅ClN₂O₂
分子量	182.65
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite

Human Endogenous Metabolite

体内研究(In Vivo)

L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement is observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione. L-lysine supplementation almost completely ameliorates vascular calcification. Dietary L-lysine strongly suppresses plasma intact parathyroid hormone in adenine rats and supports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine, and homoarginine but not lysine. The dose-dependent delay in gastric emptying observed in rats is confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine).

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

结构分类

Amino acids

来源

a genetically modified strain of Escherichia coli.

参考文献

[1]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Information]

[2]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009. [Information]

[3]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Information]

溶解度数据

体外研究:

H₂O : 100 mg/mL (547.50 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.4750 mL	27.3748 mL	54.7495 mL
5 mM	1.0950 mL	5.4750 mL	10.9499 mL
10 mM	0.5475 mL	2.7375 mL	5.4750 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 50 mg/mL (273.75 mM); Clear solution; Need ultrasonic

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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