Oxyresveratrol.|29700-22-9|(氧化白藜芦醇; trans-Oxyresveratrol)-陌孚医药/Medlife

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Oxyresveratrol. (Synonyms: 氧化白藜芦醇; trans-Oxyresveratrol)

目录号: PC17214 纯度: ≥98%

CAS No. :29700-22-9

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中文名称

Oxyresveratrol.

中文别名

氧化白藜芦醇;4-[(E)-2-(3,5-二羟基苯基)乙烯基]苯-1,3-二醇;氧化白黎芦醇;Oxyresveratrol 氧化白藜芦醇;经氧化白藜芦醇;氧化白藜芦醇标准品;氧化白藜芦醇1;氧化白藜芦醇对照品;找氧化白藜芦醇;2,4,3',5'-四羟基二苯乙烯;2,4,3',5'-四羟基茋;2,3',4,5'-四羟基-反-二苯乙烯

英文名称

Oxyresveratrol

英文别名

Oxyresveratrol;4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol;(E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol;trans-Oxyresveratrol;2,3',4,5'-Tetrahydroxy-trans-stilbene;2,4,3',5'-Tetrahydroxystilbene;3,4,3',5'-tetrahydroxy-trans-stilbene;OXYLRESVERATROL;Puag-haad;trans-2,3',4,5'-tetrahydroxystilbene;(E)-2,3′,4,5′-Stilbenetetrol;2,3′,4,5′-Tetrahydroxy-trans-stilbene;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;[ "" ];4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol;Hydroxyresveratrol;Tetrahydroxystilbene;6V071CP5CR;1,3-Benzenediol, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;2,3',4,5'-Tetrahydroxystilbene;Oxyresveratrol A;AK158555;4-(3,5-Dihydroxystyryl

Cas No.

29700-22-9

分子式

C₁₄H₁₂O₄

分子量

244.24

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.

性状

Solid

IC50 & Target[1][2]

HSV-1

HSV-2

体外研究(In Vitro)

Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC₅₀ of 45.31 μM) in murine microglial cells.
Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity.
Oxyresveratrol exhibits 63.3% inhibition at 100 μM and an IC₅₀ value of 52.7 μM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 μM and higher concentrations on murine tyrosinase activity.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Wistar rats (300-350 g) with middle cerebral artery occlusion (MCAO)
Dosage:	2 mg/kg, 10 mg/kg, 20 mg/kg and 30 mg/kg
Administration:	Intraperitoneal injection; twice (at the time of occlusion and at the time of reperfusion)
Result:	Reduced the brain infarct volume in MCAO rats.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

结构分类

Stilbenes

来源

参考文献

[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003). [Information]

[2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002). [Information]

[3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107. [Information]

[4]. Vimolmas Lipipun, et al. Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice. Antiviral Res. 2011 Aug;91(2):154-60. [Information]

溶解度数据

体外研究:

DMSO : 50 mg/mL (204.72 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.0943 mL	20.4717 mL	40.9433 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.24 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液
2.

建议依照次序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.24 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

建议依照次序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (10.24 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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