MRS 2500 tetraammonium salt|630103-23-0|-陌孚医药/Medlife

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MRS 2500 tetraammonium salt

目录号: PC10888 纯度: ≥98%

CAS No. :630103-23-0

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中文名称	MRS 2500 tetraammonium salt
英文名称	MRS 2500 tetraammonium salt
英文别名	Bicyclo[3.1.0]hexane-1-methanol,4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-,dihydrogen phosphate (ester), tetraammonium salt, (1R,2S,4S,5S)-;MRS 2500 tetraammonium salt;MRS2500 tetraammonium
Cas No.	630103-23-0
分子式	C₁₃H₁₈N₅O₈P₂I^.₄[H₃N]
分子量	629.28
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (K_i=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Antithrombotic activity.

性状

Solid

体外研究(In Vitro)

MRS2500 tetraammonium inhibits platelet aggregation to 10 μM ADP with an IC₅₀ of 0.95 nM in human washed platelets. MRS2500 tetraammonium inhibits platelet aggregation to 10μM ADP with an IC₅₀ of 0.49 μM in human PRP.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

MRS2500 (2 mg/kg; i.v.) decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor.
MRS2500 exhibited strong antithrombotic efficacy in the prevention of arterial thrombosis in the monkey ECAT model..

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-25 g WT Male mice (acute vascular occlusion model)
Dosage:	2 mg/kg
Administration:	Intravenous
Result:	Reduced platelet consumption.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Cattaneo M, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004;68(10):1995-2002. [Information]

[2]. Wong PC, et al. The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys. J Thromb Thrombolysis. 2016;41(3):514-521. [Information]

[3]. Hechler B, et al. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2-deoxyadenosine-3,5-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther. 2006;316(2):556 [Information]

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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