bpV(HOpic) (potassium salt, technical grade)|722494-26-0|-陌孚医药/Medlife

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bpV(HOpic) (potassium salt, technical grade)

目录号: PC10235 纯度: ≥98%

CAS No. :722494-26-0

商品编号	规格	价格	会员价	是否有货	数量
PC10235-25mg	25mg	¥1987.44	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

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中文名称	bpV(HOpic) (potassium salt, technical grade)
英文名称	bpV(HOpic) (potassium salt, technical grade)
英文别名	bpV(HOpic) (potassium salt);BPV(HOPIC);bpV(HOpic) (potassium salt, technical grade);Bisperoxovanadium(HOpic);Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V);K2[VO(O2)2C6H4NO3];AK00779020;Bpv (HOpic) 722494-26-0
Cas No.	722494-26-0
分子式	C₆H₇K₂NO₈V
分子量	350.26
包装储存	Sealed and stored at -20℃, moisture-proof *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

生物活性

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC₅₀ of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.

性状

Solid

IC50 & Target[1][2]

IC50: 14 nM (PTEN)

体外研究(In Vitro)

BpV(HOpic) (1 μM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment.
Bpv(HOpic) (1 μM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways.
BpV(HOpic) (1 μM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans.
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo.
BpV(HOpic) (200?μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI).

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats are subjected to partial hepatic ischemia
Dosage:	0.05 mg/kg
Administration:	I.p. injections at the start of reperfusion
Result:	Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.

Animal Model:	Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia
Dosage:	200?μg/kg
Administration:	I.p. injections 1?h before ischemia and then administers every 6?h after ischemia for 24 hr
Result:	Raised the level of serum creatinine and blood serum urea nitrogen.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed and stored at -20℃, moisture-proof

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

参考文献

[1]. Schmid AC, et, al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21; 566(1-3): 35-8. [Information]

[2]. Kim MS, et, al. Nanotherapeutics of PTEN Inhibitor with Mesoporous Silica Nanocarrier Effective for Axonal Outgrowth of Adult Neurons. ACS Appl Mater Interfaces. 2016 Jul 27; 8(29): 18741-53. [Information]

[3]. Zhang B, et, al. Silencing of miR-19a-3p enhances osteosarcoma cells chemosensitivity by elevating the expression of tumor suppressor PTEN. Oncol Lett. 2019 Jan; 17(1): 414-421. [Information]

[4]. Dimchev GA, et, al. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration 体外研究. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 2013 May; 34(2): 125-36. [Information]

[5]. Raffel N, et, al. The effect of bpV(HOpic) on 体外研究 activation of primordial follicles in cultured swine ovarian cortical strips. Reprod Domest Anim. 2019 Aug; 54(8): 1057-1063. [Information]

[6]. Ponte CD, et, al. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr; 17(4): 474-82. [Information]

[7]. Zhou J,et, al. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 Aug 25; 7(1): 9503. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (143.99 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2.89 mg/mL (8.32 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8799 mL	14.3993 mL	28.7985 mL
5 mM	0.5760 mL	2.8799 mL	5.7597 mL
10 mM	0.2880 mL	1.4399 mL	2.8799 mL

建议根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备溶液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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