L-NMMA acetate|53308-83-1|(Tilarginine acetate; Methylarginine acetate)-陌孚医药/Medlife

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L-NMMA acetate (Synonyms: Tilarginine acetate; Methylarginine acetate)

目录号: PC15162 纯度: ≥98%

CAS No. :53308-83-1

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中文名称	L-NMMA acetate
中文别名	Nω-单甲基-L-精氨酸乙酸盐;N-单甲基-L-精氨酸单乙酸酯;NG-单甲基-L-精氨酸乙酸盐;N5-(亚氨基(甲基氨基)甲基)-L-鸟氨酸单乙酸盐;NG-单甲基-L-精氨酸醋酸盐;Nomega-Monomethyl-L-arginine Acetate Nω-单甲基-L-精氨酸乙酸盐;柠檬酸二钠盐1.5水合物;N5-[亚氨基(甲基氨基)甲基]-L-鸟氨酸单乙酸盐
英文名称	L-NMMA acetate
英文别名	Ng-monomethyl-l-arginine acetate;Nomega-Monomethyl-L-arginine Acetate;L-NMMA (acetate);L-NMMA acetate;L-NMMA acetate (L-NG-monomethyl Arginine acetate, ANO 1020, Tilarginine Acetate, Targinine Acetate );NG-METHYL-L-ARGININE ACETATE;NG-Monomethyl-L-argi;ANO 1020;H-ARG(ME)-OH ACOH;L-NMMA;L-NMMA MONOACETATE;L-NMMA,ACETATE SALT;NG-ME-L-ARG,ACOH;NG-Methyl-L-arginine acetate salt;NG-Monomethyl-L-arginine monoacetate;NMMA;NMMA ACETATE SALT;Nω-Methyl-L-arginine Acetate;Nω-Monomethyl-L-arginine Acetate;Tilarginine Acetate;Nω-Methyl-L-arginine acetate salt;N5-(Methylamidino)-L-ornithine acetate salt;NG-Monomethyl-L-arginine acetate salt
Cas No.	53308-83-1
分子式	C₉H₂₀N₄O₄
分子量	248.28
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The K_i values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

性状

Solid

IC50 & Target[1][2]

eNOS

iNOS

nNOS

体外研究(In Vitro)

L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91. [Information]

[2]. Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103(4):1970-2. [Information]

[3]. Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261(1 Pt 2):H46-52. [Information]

溶解度数据

体外研究:

H₂O : ≥ 50 mg/mL (201.39 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.0277 mL	20.1386 mL	40.2771 mL
5 mM	0.8055 mL	4.0277 mL	8.0554 mL
10 mM	0.4028 mL	2.0139 mL	4.0277 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 100 mg/mL (402.77 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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