Dabigatran etexilate (BIBR 1048; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.
Dabigatran etexilate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.
Dabigatran etexilate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: |
Male rats (280-350 g) and rhesus monkeys of either sex (3-8 kg) |
Dosage: |
10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys |
Administration: |
Oral |
Result: |
Had dose- and time-dependent anticoagulant effects.
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