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Neosperidin dihydrochalcone (Synonyms: 新橙皮苷二氢查尔酮; Neohesperidin DC; NHDC)
目录号: PC13899 纯度: ≥98%
CAS No. :20702-77-6
商品编号 规格 价格 会员价 是否有货 数量
PC13899-100mg 100mg ¥441.00 请登录
PC13899-500mg 500mg ¥637.00 请登录
PC13899-1g 1g ¥862.40 请登录
PC13899-5g 5g ¥1773.80 请登录
PC13899-10mM (in 1mL DMSO) 10mM (in 1mL DMSO) ¥686.00 请登录
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中文名称
Neosperidin dihydrochalcone
中文别名
新橙皮甙二氢查尔酮;新橙皮苷二氢查耳酮;新橙皮苷二氢查尔酮;新橙皮苷二氢查耳酮水合物;Neohesperidin Dihydrochalcone Hydrate 新橙皮苷二氢查耳酮水合物;NEOHESPERIDIN 二氢查耳酮(P);新橙皮甙二氢查尔酮 USP标准品;新橙皮甙二氢查耳酮;新橙皮苷二氢查尔酮 标准品;新橙皮苷二氢查尔酮(标准品);新橙皮苷二氢查尔酮(新橙皮甙二氢查尔酮);新橙皮苷二氢查尔酮, 来源于柚子皮;新橙皮苷二氢查尔酮,Neosperidin dihydrochalcone,植物提取物,标准品,对照品;新桔皮苷-二氢查耳酮 EP标准品;新橘皮苷二氢查耳酮;新橙皮甙二氢查尔酮,Neosperidin dihydrochalcone;新橙皮甙双氢查尔酮
英文名称
Neosperidin dihydrochalcone
英文别名
Neohesperidin dihydrochalcone;neohesperidin dihydrochalcone from*citrus fruit;Neohesperidin Dihydrochalcone Hydrate;Neosperidin dihydrochalcone;1-Propanone,1-[4-[[2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-;Neohesperidin Dihydr;Neohesperidin;Neohesperidine Dihydrochalcone;E-959;FEMA 3811;Neohesperidin DC;Neohesperidin DHC;NEOHESPERIDINE DC;Neohesperidine Dihydrochalcone,NHDC;Neohesperidine hydrate;Neosperidin Dihydro halcone;NHDC;1-(4-((2-O-[6-Deoxy-α-L-mannopyranosyl]-β-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone;1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone;[ "" ];neohesperidin dihydrochalcone;Neohesperidine;3X476D83QV;Neohesperidin Dihydrochalcone (Nhdc);1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one;Neohesperidin-dihydrochalcone;3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-
Cas No.
20702-77-6
分子式
C28H36O15
分子量
612.58
包装储存
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
生物活性

Neohesperidin dihydrochalcone is a synthetic glycoside chalcone, is added to various foods and beverages as a low caloric artificial sweetener.

性状

Solid

体外研究(In Vitro)

Neohesperidin dihydrochalcone shows remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, neohesperidin dihydrochalcone is the most potent inhibitor of H2O2 and HOCl. Neohesperidin dihydrochalcone shows HOCl scavenging activity of 93.5% and H2O2 scavenging property of 73.5%. Neohesperidin dihydrochalcone shows extensive inhibitory effect especially on non-radical ROS H2O2 and HOCl with IC50 values of 205.1, 25.5 μM. Neohesperidin dihydrochalcone is found to be an activator of porcine pancreatic alpha-amylase (PPA) with an IC50 of 389 μM.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Neohesperidin dihydrochalcone administration results in significant reduction in activities of two useful markers of liver damage, AST and ALT. The relative levels of NF-κB, IL-6, IL-1β and TNF-α protein in the liver of PQ-treated mice are inhibited by neohesperidin dihydrochalcone. The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone is examined in Wistar Crl:(WI)WU BR rats. No adverse effects are observed at neohesperidin dihydrochalcone levels of up to 5% of the diet, the highest dose level tested, at which the rats consumed about 3.3 g/kg body weight/day.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
结构分类
来源
参考文献
溶解度数据
体外研究: 

DMSO : 100 mg/mL (163.24 mM; Need ultrasonic)

配制储备溶液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6324 mL 8.1622 mL 16.3244 mL
5 mM 0.3265 mL 1.6324 mL 3.2649 mL
10 mM 0.1632 mL 0.8162 mL 1.6324 mL
*

产品不同,其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液;配成溶液后,建议分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,建议在 6 个月内使用,-20°C 储存时,建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    建议依照次序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.08 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH?O 中,得到澄清透明的生理盐水溶液
  • 2.

    建议依照次序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.08 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    建议依照次序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.08 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.08 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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