Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model.

Solid

IC50: Heme oxygenase-1 (HO-1)

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

Sealed and stored at -20℃, moisture-proof

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.  [Information]

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。