Piperine.|94-62-2|(胡椒碱; Bioperine; 1-Piperoylpiperidine)-陌孚医药/Medlife

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Piperine. (Synonyms: 胡椒碱; Bioperine; 1-Piperoylpiperidine)

目录号: PC13441 纯度: ≥98%

CAS No. :94-62-2

商品编号	规格	价格	会员价
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PC13441-1g	1g	¥558.60	请登录
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PC13441-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥490.00	请登录

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中文名称

Piperine.

中文别名

胡椒碱;(E,E)-1-[5-(1,3-苯并二氧戊环-5-基)-1-氧代-2,4-戊二烯基]-哌啶;1-(5-(1,3-苯并二氧代-5-基)-1-氧代-2,4-戊二烯基(-(E,E)-哌啶;胡椒酰胺;1-胡椒醯哌啶;胡椒鹼;胡椒辣碱;Piperine 胡椒碱;番泻叶提取物;黑胡椒油树脂;胡椒碱 EP标准品;胡椒碱标准品;胡椒碱（标准品）;胡椒碱,CP;胡椒碱,Piperine,植物提取物,标准品,对照品;胡椒碱,对照品;胡椒碱[黑胡椒提取物];胡椒碱Piperine;花椒精油;花椒精油（青花椒）;花椒油;麻椒精油;(E,E)-1-[5-(1,3-苯并二氧戊环-5-基)-1-氧代-2,4-戊二烯基]-哌啶 1-(5-(1,3-苯并二氧代-5-基)-1-氧代-2,4-戊二烯基(-(E,E)-哌啶;1-胡椒酰哌啶;胡椒碱,胡椒酰胺;胡椒碱，胡椒提取物，黑胡椒提取物

英文名称

Piperine

英文别名

Piperine;N-PIPEROYLPIPERIDIN;(E,E)-1-[5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-piperidine;FEMA 2909;5-BENZO[1,3]DIOXOL-5-YL-1-PIPERIDIN-1-YL-PENTA-2,4-DIEN-1-ONE;1-PIPERONYLPIPERIDINE;1-PIPEROYLPIPERIDINE;1-PIPERYLPIPERIDINE;Piperin;PIPERINE(P);PIPERINE(P) PrintBack;PIPERINE(RG);(E,E)-1-Piperoylpiperidine;Bioperine;PIPERLINE;Piperylpiperidine;trans,trans-1-piperoylpiperidine;1-[5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine;black pepper extract, peperine;Piperoylpiperidine;FEMA No. 2909;N-[(E,E)-Piperoyl]piperidine;Piperidine, 1-piperoyl-, (E,E)-;Piperine (aliphatic);1-Piperoylpiperidine, (E,E)-;1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine;N-(E,E)-piperoyl-piperidine;piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-;U71XL721QK;MXXWOMGUGJBKIW-YPCII

Cas No.

94-62-2

分子式

C₁₇H₁₉NO₃

分子量

285.34

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC₅₀ value of 61.94±0.054 μg/mL in HeLa cell.

性状

Solid

IC50 & Target[1][2]

IC50: 61.94±0.054 μg/mL (P-glycoprotein, HeLa cell)

体外研究(In Vitro)

Piperine has shown to possess 体外研究 cytotoxic activity and in silico studies. The IC₅₀ value is found to be 61.94±0.054 μg/mL and in silico studies, it has more number of hydrogen bonds with minimum binding and docking energy and may be considered as inhibitor of EGFR tyrosine kinase. Piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties. Piperine could enhance the bioavailabilities of other drugs including rosuvastatin, peurarin and docetaxel (DOX) via inhibition of CYP3A and P-glycoprotein activity.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

At the dose of 3.5 mg/kg, the bioavailability of piperine is calculated to be 25.36%. Its AUC_0→t is unproportionally increased with doses, indicating a potential non-linear pharmacokinetics profile of piperine. It is found that the AUC_0→t and C₀ of docetaxel and t1/2of piperine are significantly increased after their combination use, suggesting potential enhanced bioavailability of not only docetaxel but also piperine, which may lead to the overall enhanced pharmacological effects. The phosphorylation of I-κB, p65, p38, ERK, and JNK is inhibited by piperine in a dose-dependent manner, indicating that piperine may be a potential anti-inflammatory drug both in endometritis and in other S. aureus-induced diseases.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

来源

参考文献

[1]. Paarakh PM, et al. 体外研究 cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [Information]

[2]. Meghwal M,et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [Information]

[3]. Li C, et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [Information]

[4]. Zhai WJ, et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208. [Information]

溶解度数据

体外研究:

DMSO : 50 mg/mL (175.23 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5046 mL	17.5230 mL	35.0459 mL
5 mM	0.7009 mL	3.5046 mL	7.0092 mL
10 mM	0.3505 mL	1.7523 mL	3.5046 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.76 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液
2.

建议依照次序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.76 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

建议依照次序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.76 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.76 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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