您当前的位置:
Ubiquitin Isopeptidase Inhibitor I
目录号: PC16255 纯度: ≥98%
CAS No. :108477-18-5
商品编号 规格 价格 会员价 是否有货 数量
PC16255-5mg 5mg ¥1358.28 请登录
PC16255-10mg 10mg ¥2442.16 请登录
PC16255-25mg 25mg ¥5433.12 请登录
Medlife所售产品仅用于科学研究(非临床研究),非药品不可食用,不可用于人体或动物的临床诊断和治疗,我们不为个人提供产品及服务。产品COA等资料,可至下方“质量控制”中下载。
中文名称
Ubiquitin Isopeptidase Inhibitor I
中文别名
Ubiquitin Isopeptidase Inhibitor I, G5
英文名称
Ubiquitin Isopeptidase Inhibitor I
英文别名
3,5-bis-((Ξ)-4-nitro-benzylidene)-1,1-dioxo-tetrahydro-1λ6-thiopyran-4-one;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide;Ubiquitin Isopeptidase Inhibitor I, G5;NSC-144303;Ubiquitin Isopeptidase Inhibitor I;G5, Ubiquitin Isopeptidase Inhibitor I;(3Z,5Z)-3,5-bis[(4-nitrophenyl)methylidene]-1,1-dioxothian-4-one;Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one 1,1-dioxide;BDBM50072959;3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-,1,1-dioxide;4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)m
Cas No.
108477-18-5
分子式
C19N2O7SH14
分子量
414.39
包装储存
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

生物活性

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

性状

Solid

IC50 & Target[1][2]

IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)

体外研究(In Vitro)

G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

参考文献
溶解度数据
体外研究: 

DMSO : 50 mg/mL (120.66 mM; Need ultrasonic)

THF : 3.44 mg/mL (8.30 mM; Need ultrasonic)

Acetone : 2.86 mg/mL (6.90 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

配制储备溶液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4132 mL 12.0659 mL 24.1319 mL
5 mM 0.4826 mL 2.4132 mL 4.8264 mL
10 mM 0.2413 mL 1.2066 mL 2.4132 mL
*

建议根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备溶液;该产品在溶液状态不稳定,建议您现用现配,即刻使用

搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2