Neuromedin B (porcine)|87096-84-2|(神经介素 B)-陌孚医药/Medlife

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Neuromedin B (porcine) (Synonyms: 神经介素 B)

目录号: PC10865 纯度: ≥98%

CAS No. :87096-84-2

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中文名称

Neuromedin B (porcine)

中文别名

神经介素B;猪神经调节肽 B

英文名称

Neuromedin B (porcine)

英文别名

Neuromedin B (swinespinal cord) (9CI);Neuromedin B;GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2;Neuromedin B (porcine);NEUROMEDIN B, PORCINE;Neuromedin BNeuromed;GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2 ACOH 5H2O;Gly-L-Asn-L-Leu-L-Trp-L-Ala-L-Thr-Gly-L-His-L-Phe-L-Met-NH2;GNLWATGHFM-NH2;H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2;LEU-SER-TRP-ASP-LEU-PRO-GLU-PRO-ARG-SER-ARG-ALA-GLY-LYS-ILE-ARG-VAL-HIS-PRO-ARG-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2: LSWDLPEPRSRAGKIRVHPRGNLWATGHFM-NH2;NEUROMEDIN B,PORCINE MAMMALIAN BOMBESIN-LI;neuromedin-B;Neuromedin B (pig spinal cord);Pig neuromedin B

Cas No.

87096-84-2

分子式

C₅₂H₇₃N₁₅O₁₂S

分子量

1132.29

包装储存

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体外研究(In Vitro)

Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC₅₀) is only 5% of BN (EC₅₀ of BN/EC₅₀ of NMB) and about 10% of GRP (EC₅₀ of GRP/ EC₅₀ of NMB).

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED₅₀ of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SequenceShortening

GNLWATGHFM-NH2

Sequence

Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2

结构分类

Others

来源

mammals

参考文献

[1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312. [Information]

溶解度数据

体外研究:

H₂O : 12.5 mg/mL (11.04 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8832 mL	4.4158 mL	8.8317 mL
5 mM	0.1766 mL	0.8832 mL	1.7663 mL
10 mM	0.0883 mL	0.4416 mL	0.8832 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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