Colistin Sulfate.|1264-72-8|(硫酸粘杆菌素; Polymyxin E sulfate)-陌孚医药/Medlife

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Colistin Sulfate. (Synonyms: 硫酸粘杆菌素; Polymyxin E sulfate)

目录号: PC11684 纯度: ≥98%

CAS No. :1264-72-8

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中文名称	Colistin Sulfate.
中文别名	多粘菌素;多粘菌素硫酸盐;黏菌素硫酸盐;硫酸粘菌素;硫酸黏素菌;硫酸多粘霉素E;硫酸粘杆霉素;硫酸粘杆菌素;粘杆菌素;多粘菌素E硫酸盐;硫酸抗敌素 (混合物);Colistin Sulfate (mixture) 硫酸抗敌素 (混合物);Colistin Sulphate 多粘菌素E硫酸盐;阿塔凝胶;多粘菌素（硫酸粘杆菌素）;硫酸粘杆菌;阿莫沙平;多粘菌素E 标准品;抗敌素盐酸盐;抗生素类药;硫酸黏菌素;硫酸粘杆菌素,Colistin sulfate salt ,分析标准品;粘杆菌素B;碳酸钾-13C;美海屈林萘二磺酸盐;硫酸粘菌素微生物鉴定 EP标准品;硫酸粘菌素标准品;硫酸粘菌素、克利斯汀(Colistin)、多粘菌素E(Polymyxin E)、抗敌素;硫酸粘菌素 EP标准品;硫酸粘杆霉菌;硫酸粘杆菌素标准品;硫酸粘杆菌素, 硫酸粘菌素;硫酸粘杆菌素 USP标准品
英文名称	colistin sulfate
英文别名	colistin sulfate;n-[3-amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate;Colistin Sulphate;Colistin Sulfate (mixture);Colistin sulfate (USP Grade);Colistin sulfate salt;Polymyxin E Sulfate;Colistin sulfate salt,Polymyxin E;Polymyxin E;Polymyxin?E;Polymyxin E;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-;N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate
Cas No.	1264-72-8
分子式	C₁₀₄H₂₀₆N₃₂O₄₆S₅
分子量	2801.26
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

性状

Solid

体外研究(In Vitro)

Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

结构分类

来源

Bacillus polymyxa var. colistinus

参考文献

[1]. Hancock RE et al. Peptide antibiotics. Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23. [Information]

[2]. Li J, et al. 体外研究 pharmacodynamic properties of colistin and colistin methanesulfonate againstPseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother. 2001 Mar;45(3):781-5. [Information]

[3]. W S Yapa S, et al. Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections. Antimicrob Agents Chemother. 2013 Oct;57(10):5087-95. [Information]

[4]. Fleury MA, et al. Impact of two different colistin dosing strategies on healthy piglet fecal microbiota. Res Vet Sci. 2016 Aug;107:152-60. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (35.70 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.7140 mL	3.5698 mL	7.1396 mL
5 mM	0.1428 mL	0.7140 mL	1.4279 mL
10 mM	0.0714 mL	0.3570 mL	0.7140 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 50 mg/mL (35.70 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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