Sarafloxacin HCl|91296-87-6|-陌孚医药/Medlife

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Sarafloxacin HCl

目录号: PC11696 纯度: ≥98%

CAS No. :91296-87-6

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中文名称	Sarafloxacin HCl
中文别名	盐酸沙拉沙星;1-对氟苯-6-氟-4-氧代-1,4-二氢-7-(1-哌嗪基)-3-喹啉羧盐水合物;沙拉沙星盐酸盐;6-氟-1-(4-氟苯基)-4-氧代-7-哌嗪-1-基喹啉-3-羧酸盐酸盐;6-氟-1-(4-氟苯基)-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉羧酸盐酸盐;盐酸沙氟沙星;WAKO195-14211盐酸沙拉沙星标准品;沙拉沙星盐酸盐标准品;左旋哌乙酯盐酸盐;6-氟-1-(4-氟苯基)-1,4-二氢-4-氧代-7-(1-哌嗪基)-3-喹啉甲酸盐酸盐;沙氟沙星杂质
英文名称	Sarafloxacin HCl
英文别名	Sarafloxacin hydrochloride;6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid hydrochloride;6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;Sarafloxacin (hydrochloride);Sarafloxacin HCl;Sarafloxacin Hydroch;Sarafloxacin hydrochloride hydrate;6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hydrochloride;I36JP4Q9DF;Sarafloxacin hydrochloride [USAN];Saraflox;AK126668;DSSTox_RID_81237;DSSTox_CID_25939;DSSTox_GSID_45939;6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;PD 121960;Sarafloxacin hydrochloride (
Cas No.	91296-87-6
分子式	C₂₀H₁₈ClF₂N₃O₃
分子量	421.83
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Sarafloxacin (hydrochloride) (A-56620 (hydrochloride)) is a quinolone antibiotic drug.

性状

Solid

IC50 & Target[1][2]

Quinolone

体外研究(In Vitro)

Sarafloxacin (hydrochloride) is a fluoroquinolone antibiotic registered for use against poultry diseases. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, respectively, at the termination of the test. The inhibitory level of sarafloxacin for the tested bacteria was strain dependent. It appeared that in broth culture Escherichia coli isolates were sensitive to sarafloxacin concentrations 5-fold lower than the concentrations present in the simulated gut model, suggesting that sarafloxacin may be partially unavailable due to absorption to organic matter in the model.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Administering Sarafloxacin (hydrochloride) in the feed for 5 d at a dose of 10 or 12.5 mg/kg of fish proved efficacious in treating channel catfish infected with E. ictaluri in all three field trials. Average survival of the nonmedicated group was 43% in trial 1, 11°% in trial 2, and 59% in trial 3. Survival of the corresponding Sarafloxacin hydrochloride-medicated groups averaged 68, 48, and 73%. Antibiotic therapy with Sarafloxacin hydrochloride significantly (P < 0.05) improved survival in all trials.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. Marengo, J.R., et al., Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry, 1997. 16(3): p. 462-471.

[2]. McConville, M.L., et al., Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions. Vet Q, 1995. 17(1): p. 1-5. [Information]

[3]. Johnson, M.R., K.L. Smith, and C.R. Boyle, Field efficacy trials of the antibacterial sarafloxacin-hydrochloride (A-56620) for treatment of Edwardsiella ictaluri infections in channel catfish. Journal of aquatic animal health, 1992. 4(4): p. 244-251.

溶解度数据

体外研究:

DMSO : 8.33 mg/mL (19.75 mM; Need ultrasonic)

H₂O : 1 mg/mL (2.37 mM; ultrasonic and warming and heat to 60°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3706 mL	11.8531 mL	23.7062 mL
5 mM	0.4741 mL	2.3706 mL	4.7412 mL
10 mM	0.2371 mL	1.1853 mL	2.3706 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.97 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH?O 中，得到澄清透明的生理盐水溶液
2.

建议依照次序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.97 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

建议依照次序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 0.83 mg/mL (1.97 mM); Clear solution

此方案可获得 ≥ 0.83 mg/mL (1.97 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 8.3 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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