(S)-Methylisothiourea sulfate.|867-44-7|(S-甲基异硫脲半硫酸盐)-陌孚医药/Medlife

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(S)-Methylisothiourea sulfate. (Synonyms: S-甲基异硫脲半硫酸盐)

目录号: PC15164 纯度: ≥98%

CAS No. :867-44-7

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PC15164-10mM (in 1mL H2O)	10mM (in 1mL H2O)	¥490.00	请登录

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中文名称	(S)-Methylisothiourea sulfate.
中文别名	S-甲基异硫脲硫酸盐;2-甲基-2-硫代异尿素硫酸氢盐;2-甲基-2-硫代假脲半硫酸盐;2-甲基-2-疏基硫酸脲;2-甲基-2-异硫脲半硫酸盐;O-甲基异脲硫酸盐;S-甲基异硫脲半硫酸盐;硫酸S-甲基硫脲;2-甲基-2-硫代异尿素硫酸盐;2-甲基异硫脲硫酸盐;JS-甲基异硫脲硫酸盐;S-甲基-ITU;S-甲基异硫脲;甲基异硫脲硫酸盐;S-甲基硫代异尿素硫酸氢盐;2-甲基-2-硫代假脲半硫酸盐
英文名称	Carbamimidothioic acid, methyl ester
英文别名	2-Methyl-2-thiopseudourea hemisulfate;S-Methylisothiourea sulphate;2-Methyl-2-thiopseudourea sulphate;S-Methylisothiourea hemisulfate salt;S-Methylisothiouronium sulphate;s-Methyl-Iso-Thiourea;S-EIT hemihydrate;S-Methylisothiouronium sulfate;(S)-Methylisothiourea sulfate;2-METHYL-2-THIOPSEUDOUREA HEMISULFATE HEMIHYDRATE;2-Methyl-2-thiopseudourea sulfate;2-METHYL-ISOTHIOUREA;METHYL IMIDOTHIOCARBAMATE SULFATE;S-methyl Isothiourea (hemisulfate);S-Methylisothiourea Sulfate;S-Methyl-isothiouron;S-Methyl-isothiouronium Hemisulfate;S-METHYLTHIOUREA SULFATE;methyl imidothiocarbamate;S-methyl-2-thiopseudourea hydrogen sulfate;S-Methylisothiourea hemisulfate;S-METHYLISOTHIOUREA HEMISULFATE SALT _X000D_;S-methylisothiourea hydrogensulfate;S-METHYL-ISO-THIOUREA SULFATE;S-METHYLTHIOURONIUM SULFATE FOR SYNTHESIS;SMT;Bis(2-methylthiouronium) sulphate;Bis(2-methylisothiouronium) sulphate;S-Methyl isothiourea sulfate;s-methylisothiourea;methyl carbamimidothioate;S-Methyl isothiourea;Carbamimidothioic acid, methyl ester;2-methylisothiourea;S-Methyl-isothiourea;S-Methylisothiouronium;2-methyl-2-thiopseudourea;S-Methylisothiopseudouronium;S-Methylthiopseudouronium iodide;ES8C3884JW;SDDKIZNHOCEXTF-UHFFFAOYSA-N;S-Methyl-ITU;2-Methylisothio urea;S-methylthiopseudourea;S-methylpseudothiourea;PubChem2004;S-methylthiourea;PubChem
Cas No.	867-44-7
分子式	C₄N₄O₄S₃H₁₄
分子量	278.37
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock.

性状

Solid

IC50 & Target[1][2]

iNOS

体外研究(In Vitro)

S-Methylisothiourea sulfate is a competitive inhibitor of iNOS activity at the L-arginine site.
S-Methylisothiourea sulfate prevents the NO-mediated cytotoxic effect of LPS in cultured macrophages.
S-Methylisothiourea sulfate (100 nM-100 μM) exhibits inhibitory effects on LPS (ug/mL)-induced nitrite production in J774.2 macrophages and rat aortic vascular smooth muscle cells.
S-Methylisothiourea sulfate (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

S-Methylisothiourea sulfate (0.01-3 mg/kg; i.v.) dose-dependently reverses the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats.
S-Methylisothiourea sulfate (5 mg/kg; i.p.; given 2 hr after LPS; 10 mg/kg; i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS.
S-Methylisothiourea sulfate (1 mg/kg; i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg; i.p.).

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (260-320 g)
Dosage:	0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Intravenous injection
Result:	Caused a prompt restoration of the blood pressure to pre-LPS levels at 3 mg/kg dose in LPS (10 mg/kg, i.v.)-treated rats; Inhibited iNOS activity measured in homogenates of lung.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

[1]. C Szabó, et al. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26): 12472-12476. [Information]

溶解度数据

体外研究:

H₂O : 65 mg/mL (467.02 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.1849 mL	35.9247 mL	71.8494 mL
5 mM	1.4370 mL	7.1849 mL	14.3699 mL
10 mM	0.7185 mL	3.5925 mL	7.1849 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 50 mg/mL (359.25 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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