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Pyrrolidinedithiocarbamate ammonium. (Synonyms: 吡咯烷二硫代氨基甲酸铵; Ammonium pyrrolidinedithiocarbamate; PDTC ammonium; APDC)

目录号: PC11578 纯度: ≥98%

CAS No. :5108-96-3

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中文名称	Pyrrolidinedithiocarbamate ammonium.
中文别名	吡咯烷二硫代甲酸铵;1-吡咯烷硫代羧酸铵盐;吡咯二硫代甲酸铵;1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代氨基甲酸铵;四次甲基二硫代氨基甲酸铵;四亚甲基二硫代氨基甲酸铵;1-吡咯烷羰基二硫酸铵盐;吡咯烷二硫代甲酸铵盐;1-吡咯烷二硫代甲酸铵[原子吸收分析用试剂];1-吡咯啶二硫羧酸铵;Ammonium 1-Pyrrolidinecarbodithioate [Reagent for Atomic Absorption Analysis] 1-吡咯烷二硫代甲酸铵[原子吸收分析用试剂];吡咯烷二硫代氨基甲酸钠;1-吡咯烷二硫代甲酸铵;吡咯烷二硫氨基甲酸;四亚甲基二硫代氨基甲酸铵, 1-吡咯烷二硫代羧酸铵盐,吡咯烷二硫代氨基甲酸铵;1-吡咯烷二硫代羧酸铵盐
英文名称	Pyrrolidinedithiocarbamate ammonium
英文别名	1-Pyrrolidinecarbodithioic acid, ammoniumsalt;Ammonium pyrrolidinedithiocarbamate~APDC;APDC;APDTC;Pyrrolidinedithiocarbamate;ammonium pyrrolidine-1-carbodithioate;Ammonium tetramethylenedithiocarbamate;PYRROLIDINE-N-DITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMATE AMMONIUM;PYRROLIDINEDITHIOCARBAMATE, AMMONIUM DERIVATIVE;PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT;PYRROLIDINEDITHIOCARBAMIC ACID AMMONIUM SALT;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMONIUM SALT;Ammonium pyrrolidinedithiocarbamate;Ammonium 1-Pyrrolidinecarbodithioate [Reagent for Atomic Absorption Analysis];Ammonium 1-pyrrolidinedithiocarbamate;PDTC (PDC, APDC, Pyrrolidinedithiocarbamate Ammonium);Pyrrolidinedithiocarbamate (ammonium);1-PYRROLIDINECARBODITHIOIC ACID;1-Pyrrolidinecarbodithioic acid ammonium salt,APDC,Ammonium pyrrolidinecarbodithioate;1-Pyrrolidinedithiocarboxylic acid ammonium salt;Ammonium 1-Pyrrolidinecarbodithioate;Ammonium pyrrolidine;Ammonium Pyrrolidine-N-dithiocarbamate;Ammoniumpyrrolidinedithiocarb;APCD;APDC AMMONIUM SALT;APDTC AMMONIUM SALT;PDC;PDTC;Pyrrolindinedithiocarbamate ammonium;1-Pyrrolidinecarbodithioic Acid Ammonium Salt;Pyrrolidine dithiocarbamate;Pyrrolidine-1-carbodithioic acid;Pyrrolidine dithiocarbamic acid;Tetramethylenedithiocarbamic acid;Pyrrolidine-N-carbodithioic acid;Ammonium pyrrolidine dithiocarbamate;1-Pyrrolidinecarbodithioic acid, ammonium salt;C5H9NS2;NSC298194;ammonium tetramethylene dithiocarbamate;NCIOpen2_00
Cas No.	5108-96-3
分子式	C₅H₉NS₂
分子量	147.26
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) is a selective and blood-brain barrier (BBB) permeable NF-κB inhibitor.

性状

Solid

IC50 & Target[1][2]

NF-κB

体外研究(In Vitro)

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6. [Information]

[2]. Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (304.34 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.0868 mL	30.4340 mL	60.8680 mL
5 mM	1.2174 mL	6.0868 mL	12.1736 mL
10 mM	0.6087 mL	3.0434 mL	6.0868 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 24 mg/mL (146.08 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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