BMS 453|166977-43-1|(BMS-189453)-陌孚医药/Medlife

您当前的位置：

BMS 453 (Synonyms: BMS-189453)

目录号: PC15226 纯度: ≥98%

CAS No. :166977-43-1

商品编号	规格	价格	会员价	是否有货	数量
PC15226-10mg	10mg	¥4429.60	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	BMS 453
中文别名	4-[(1E)-2-(5,6-二氢-5,5-二甲基-8-苯基-2-萘基)乙烯基]苯甲酸
英文名称	BMS 453
英文别名	(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid;BMS-453;BMS 453 HYDRATE;4-[(1E)-2-(5,6-Dihydro-5,5-diMethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid;(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid;BMS453;BMS 189453
Cas No.	166977-43-1
分子式	C₂₇H₂₄O₂
分子量	380.48
包装储存	-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

生物活性

BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

性状

Solid

体外研究(In Vitro)

BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis.
BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest.
BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21.
BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Normal human mammary epithelial cells (184 and HMEC)
Concentration:	1 μM
Incubation Time:	11 hours
Result:	Inhibited H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %.

Cell Cycle Analysis

Cell Line:	Normal human mammary epithelial cells (184 and HMEC)
Concentration:	1 μM
Incubation Time:	5 days
Result:	Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase.

Western Blot Analysis

Cell Line:	184 cells
Concentration:	1 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Induced Rb hypophosphorylation and decrease CDK2 kinase activity.

运输条件

Room temperature or refrigerated transportation.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献

[1]. J Y Chen, et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 Mar 15;14(6):1187-97. [Information]

[2]. L Yang, et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Oncogene. 2001 Nov 29;20(55):8025-35. [Information]

溶解度数据

体外研究:

DMSO : 16.67 mg/mL (43.81 mM; ultrasonic and warming and heat to 60°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6283 mL	13.1413 mL	26.2826 mL
5 mM	0.5257 mL	2.6283 mL	5.2565 mL
10 mM	0.2628 mL	1.3141 mL	2.6283 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation