Antagonist G|115150-59-9|-陌孚医药/Medlife

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Antagonist G

目录号: PC15051 纯度: ≥98%

CAS No. :115150-59-9

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中文名称

Antagonist G

英文名称

Antagonist G

英文别名

L-Methioninamide,L-arginyl-D-tryptophyl-N-methyl-L-phenylalanyl-D-tryptophyl-L-leucyl-;(Arg?00D-Trp?·?00N-Me-Phe?)-SubstanceP(6-11);(Arg6,D-Trp7·9,N-Me-Phe8)-Substance P (6-11);Antagonist G;ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2;(Arg6,D-Trp7?9,N-Me-Phe8)-Substance P (6-11);AntagonistG,Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2;arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide;H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2;(arg6;Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2;(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11);Substance P, fragment 6-11, [Arg6, D-Trp7,9, NMePhe8];AntagonistG, Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2;[Arg6, D-Trp7,9, N-Me-Phe8]-SubstanceP fragment6-11

Cas No.

115150-59-9

分子式

C₄₉H₆₆N₁₂O₆S

分子量

951.19

包装储存

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

生物活性

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.

性状

Solid

体外研究(In Vitro)

Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.
Antagonist G activates JNK1 in SCLC cells.
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells.
Concentration:	0-100 μM.
Incubation Time:	24 h.
Result:	Inhibited cell growh.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

SequenceShortening

RW-{Me-Phe}-WLM-NH2

参考文献

[1]. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer 体外研究. Cancer Res. 1990 Jul 1;50(13):3968-73. [Information]

[2]. A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83(7): 941–948. [Information]

溶解度数据

体外研究:

H₂O : 50 mg/mL (52.57 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0513 mL	5.2566 mL	10.5131 mL
5 mM	0.2103 mL	1.0513 mL	2.1026 mL
10 mM	0.1051 mL	0.5257 mL	1.0513 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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