Orexin B (mouse)|202801-92-1|(Rat orexin B; Orexin B (mouse))-陌孚医药/Medlife

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Orexin B (mouse) (Synonyms: Rat orexin B; Orexin B (mouse))

目录号: PC10838 纯度: ≥98%

CAS No. :202801-92-1

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中文名称

Orexin B (mouse)

中文别名

食欲肽B;食欲素

英文名称

Orexin B (mouse)

英文别名

L-Methioninamide,L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-(9CI);Orexin B (rat, mouse);L-Methioninamide,L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-...;L-Methioninamide,L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl;OREXIN B (MOUSE);Orexin B (mouse, rat);Orexin B (mouse, rat), Hypocretin-2 (mouse, rat);Orexin-B (Rat, Mouse);H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2;Hypocretin2 (Rattus norvegicus);L-Methioninamide,L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucy;Orexin B, rat, mouse;Rat orexin B;Orexin B, mouse, rat;C126H215N45O34S

Cas No.

202801-92-1

分子式

C₁₂₆H₂₁₅N₄₅O₃₄S

分子量

2936.40

包装储存

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性

Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K_is of 420 and 36 nM for OX1 and OX2, respectively.

性状

Solid

IC50 & Target[1][2]

Ki: 420 nM (OX1), 36 nM (OX2)

体外研究(In Vitro)

OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC₅₀ of 36 nM in the binding assay and an EC₅₀ of 60 nM in the [Ca]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC₅₀ in the competitive binding assay and the EC₅₀ in the [Ca]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SequenceShortening

RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2

Sequence

Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

参考文献

[1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [Information]

[2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. [Information]

[3]. Ziolkowska A, et al. Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells. Int J Mol Med. 2008;22(6):749-755. [Information]

[4]. Zhang G, et al. Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina. Neuropharmacology. 2018;133:38-50. [Information]

溶解度数据

体外研究:

H₂O : 16.67 mg/mL (5.68 mM; Need ultrasonic)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.3406 mL	1.7028 mL	3.4055 mL
5 mM	0.0681 mL	0.3406 mL	0.6811 mL
10 mM	---	---	---

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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