SNOG|57564-91-7|(GSNO; RVC-588; S-Nitroso-L-glutathione)-陌孚医药/Medlife

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SNOG (Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione)

目录号: PC15150 纯度: ≥98%

CAS No. :57564-91-7

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中文名称

SNOG

中文别名

亚硝基谷胱甘肽;S-亚硝基-L-谷胱甘肽;S-亚硝基谷胱甘肽;亚硝基谷胱甘肽（GSNO）

英文名称

SNOG

英文别名

Glycine, L-g-glutamyl-S-nitroso-L-cysteinyl-;S-Nitroso-L-glutathione;S-Nitrosylglutathione;(S)-2-Amino-5-(((R)-1-((carboxymethyl)amino)-3-(nitrosothio)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid;GSNO;N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycine (S-Nitrosoglutathione);S-NITROSOGLUTATHIONE;S-Nitroso-L-glutathi;SNOG;N-(N-L-gama-glutamyl-S-nitroso-L-cysteinyl)glycine;Nitrosoglutathione;RVC 588;RVC 588 (peptide)

Cas No.

57564-91-7

分子式

C₁₀H₁₆N₄O₇S

分子量

336.32

包装储存

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses.

性状

Solid

体外研究(In Vitro)

Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20.
Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but up-regulates endothelial NOS expression in the flap vessels.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Lewis rats.
Dosage:	0.2 and 0.6 mg/kg.
Administration:	Slow intravenous injection via the opposite femoral vein into each rat.
Result:	Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

溶解度数据

体外研究:

H₂O : 16.67 mg/mL (49.57 mM; ultrasonic and warming and heat to 60°C)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9734 mL	14.8668 mL	29.7336 mL
5 mM	0.5947 mL	2.9734 mL	5.9467 mL
10 mM	0.2973 mL	1.4867 mL	2.9734 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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