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L-Cysteinesulfinic acid (Synonyms: L-半胱氨酸亚磺酸)
目录号: PC12083 纯度: ≥98%
CAS No. :1115-65-7
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中文名称
L-Cysteinesulfinic acid
中文别名
L-半胱氨酸亚磺酸;L-半胱亚磺酸;L-半胱亚磺酸(羧甲司坦杂质) 标准品;Nk-611盐酸盐;羧甲司坦杂质;3-亚磺基-L-丙氨酸;Α-氨基-Β-亚磺基丙酸
英文名称
L-Cysteinesulfinic acid
英文别名
L-Alanine, 3-sulfino-;L -CYSTEINE SULFINIC ACID;L-CYSTEINE SULFINIC ACID, CRM STANDARD;2-amino-3-sulfino-propanoic acid;2-amino-3-sulfino-propionic acid;3-Sulfinoalanine;3-sulphino-L-alanine;Cysteine sulphinic acid;cysteinsulphinic acid;L-cysteine sulphinic acid;L-CYSTEINESULFINIC ACID 1-HYDRATE;m-Chlorophenylbiguanide hydrochloride
Cas No.
1115-65-7
分子式
C3H7NO4S
分子量
153.16
包装储存
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
生物活性

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

性状

Solid

IC50 & Target[1][2]

mGluR1

3.92 (pEC50)

mGluR2

3.9 (pEC50)

mGluR4

2.7 (pEC50)

mGluR5

4.6 (pEC50)

mGluR6

4.0 (pEC50)

mGluR8

3.94 (pEC50)

Human Endogenous Metabolite

 

体外研究(In Vitro)

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
结构分类
参考文献
溶解度数据
体外研究: 

H2O : 125 mg/mL (816.14 mM; Need ultrasonic)

配制储备溶液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.5291 mL 32.6456 mL 65.2912 mL
5 mM 1.3058 mL 6.5291 mL 13.0582 mL
10 mM 0.6529 mL 3.2646 mL 6.5291 mL
*

产品不同,其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液;配成溶液后,建议分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,建议在 6 个月内使用,-20°C 储存时,建议在 1 个月内使用。

搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2